Throughout the COVID-19 pandemic there have been key findings that have altered our understanding or required responses to this disease. For example, the realization that pre- or asymptomatic persons might be infectious has required a different approach to masking and social distancing. While we have several threads discussing the pandemic, I feel that recent developments justify a new topic, especially as it could be used to clarify potential misunderstandings.
With the delta variant (B.1.617.2) gaining dominance we are seeing yet another change that requires us to re-think the trajectory of the pandemic. First of all, the transmission rate of this variant is much higher than estimates for the original strain. The CDC has compared it to chicken pox, which has a basic reproduction number (R0) of >10.
What does it mean? First of all, this might indicate that vaccine-based herd immunity is entirely out of the picture. With a R0 of 10 you would need to have a total protection of >92% of the population. Since the effectiveness of the best vaccines against the delta variant are a bit lower than 90%, it means that even with no vaccine hesitation and even if we could vaccinate children with it, we won't hit the required target for herd immunity. This has been assumed to happen for a while now, and might be the least surprising bit of news.
However, there are a few recent findings that have prompted changes in messaging, for example with regard to masking. The key issue here are the finding that folks with breakthrough infections have similar viral loads as unvaccinated folks.
What does it mean? Fundamentally there some vaccinated folks that get infected with SARS-CoV-2. That in itself is not surprising. Historically, breakthrough infections happen for most vaccinations at low frequencies. Most of the time the focus is on illness, i.e. symptomatic manifestations of infections. However, as mentioned, the possibility of asymptomatic spread has changed that. The fact that vaccinated folks still have high titers means that folks with breakthrough infections could infect others and especially unvaccinated folks are at risk of becoming seriously ill. Vaccinated folks, for the most part do not seem to develop serious symptoms anymore, but it means that vaccinated folks could unwittingly infect and endanger un-or undervaccinated folks. This has prompted a reversal in the masking recommendation. Moreover, it has made many infectious disease experts nervous as in many countries mask mandates are being lifted.
Unknowns: There are still many open questions. For example, in the US, the delta variant is causing more illness in younger folks, including children. It is not clear whether this is really a property of the virus, or just because younger folks tend not to be vaccinated. It is not certain whether the vaccine effectively protect from long-haul COVID symptoms. The rate of breakthrough infections is unclear, we know the lower end of the estimate based on detected cases, but since folks without symptoms typically do not get tested, we do not know exact numbers. Even in a highly vaccinated community it is possible that there is a large enough reservoir to allow new variants to develop.
https://www.cdc.gov/mmwr/volumes/70/wr/mm7031e2.htm?s_cid=mm7031e2_w
https://www.medrxiv.org/content/10.1101/2021.07.31.21261387v1
Discussion points:
As a whole it means that we are heading into new territory during fall and winter. The big question is whether the current vaccination rates are good enough to prevent mass hospitalization or will easing of restrictions make folks forget that the disease is still there and cause a new surge. Vaccine hesitancy will add fuel to this potential fire.
The communication in many countries/states/provinces have been confusing to say the least and quite a few folks I have talked to seem under the impression that there is little danger left, despite the fact that even in highly vaccinated countries, especially younger folks are barely hitting 50% of full vaccinations. Moreover, most folks in the world are still unvaccinated, meaning that we will need to prepare for more variants.
Everyone is being sick and tired of the situation, yet undoubtedly the world has changed yet again (and will continue to do so). A big decision at some point is to establish how many deaths we are comfortable with. With regard to flue, for example, the number is surprisingly high across countries and by any estimate, COVID-19 is going to eclipse it, unless very high vaccination rates are maintained, which is notoriously difficult.
Edit Aug, 19, 2021:
A new preprint has come out indicating that with the Delta variant Pfizer might only be 42% effective at preventing infections (not disease!) and Moderna was about 76%.
https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v1
This seem to highlight that behavioral prevention is still going to be important.