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Showing content with the highest reputation on 10/02/21 in all areas

  1. The relevant bit here is that most of the description in OP suggest that something does not work the way it should (or at least the way it works in most folks). While most researchers would think that perhaps there is something wrong (anesthesia resistance can be a big issue in some folks and in addition to drug abuse has been associated with certain neurological conditions). Now there is some interest in finding out why that is the case (IIRC one mutation in a gene coding for a channel protein was implicated in local anesthetic resistance). However, the fun bit is that OP seems to think that these are desirable things. In most cases you want to similar to most others simply because then treatments and medication are more likely to work on you. That is in fact quite a bit of a problem as folks with rare conditions may be at higher risk as physicians may simply not be aware of these conditions and how they affect treatment. Somewhat related, a similar issue is there because many study cohorts have been historically white and male. Which is why there has been a push in having more diversity in study cohorts, if possible. There is no general term for these types of studies, it really depends on the specific question. For example, assuming that you have tolerance to a certain drug and this trait is found within your family, one might be interested in exome sequencing to see if there is a genetic component. If you have a certain condition that might result in some physiological alterations, one might be interested if those traits are also found in folks suffering from similar conditions and so on. I.e. you design your study around a highly specific question. That is actually a typical effect of caffeine withdrawal, which in turn suggest that you are in fact reacting to caffeine. My guess there is that the acid is not sufficiently concentrated to do immediate burn damage. However, please do not test that out. It is not worth it for an internet discussion.
    2 points
  2. An interim report of a phase III trial by Merck indicates that their candidate (Molnupiravir) which seems to be effective in reducing hospitalization and death in mild to moderate COVID-19 cases . https://www.merck.com/news/merck-and-ridgebacks-investigational-oral-antiviral-molnupiravir-reduced-the-risk-of-hospitalization-or-death-by-approximately-50-percent-compared-to-placebo-for-patients-with-mild-or-moderat/
    1 point
  3. Thank you all for replying. Insensitivity to pain: this has been checked into, and apparently, this is due to my Aspergers. I also can stand quite deep temperatures, but in summertime when temperature rises over 22 degrees, I start to suffer. My skin on my hands is fairly rough, but when I use battery acid to get the machine grease of my hands (which does not come off with soap), I notice no red skin, nothing. Hands are in normal shape, even after using the acid few times a day (if the machine had a rough day, and stopped a lot). As for tolerance to chemicals, my father has this as well, just like me, it's apparently with most family members of my fathers side. Oddly, this affects only the males, from what I gathered from many accounts. No doctor/specialist (Hematologist/Neurologist/...) has found out why. And no, I do not do drugs. Also, I had to drink water for a while (3 weeks), which was a horrible week for me (used to coffee), and besides a headache from lack of caffeine, I had no other effects of the lack of coffee. Going back on my coffee, also did not result in any change, physically nor mentally. Though I understand you making fun of me, might I tell you, Bufofrog and Exchemist: 1) You never met me. 2) You never heard of me. Thus, it is quite darn impolite to both judge me, and insult me with your jokes and unbelief ... "Why would acid help with grease?" This I do not know, but where soap with sandgraines failed, the battery acid does remove that stuff. Wished I could answer, but I cannot. "there is no way that healthy tissue would not get damaged." And yet, I have no known issues? Besides the above-mentioned, then. All that aside, does anyone please know the terminology, I am seeking for? Thank you. Ben
    1 point
  4. There are a couple of known conditions that result in abnormal pain perception. It is indeed something that one should consult with a physician, especially if serious cuts are not being noticed. Caffeine tolerance on the other hand is not terribly unusual. During my postdoc times I had easily two litres of coffee a day quite frequently and there was no noticeable effect. However, I tried being on decaff for 1-2 years and after that I found that coffee actually had some effects such as on heart rate. Though that vanished quickly again. Similarly, there are different conditions and issues that can cause tolerance to certain drugs, including anesthasia. Alcohol, amphetamines, opiates as well as high levels of caffeine can alter how those drugs work, for example. Why would acid help with grease? Diluted sulphuric acid often does not immediately result in noticeable damages (especially if skin is protected by a layer of grease a bit). Also, if the skin is also already in rough shape, it may become less sensitive and minor burns may not be immediately noticeable. Folks who routinely work with damaging agents (e.g. aggressive cleaning solutions) with insufficient protection often have badly cracked and damaged skin with little sensation left. However, concentrated suphuric acid will rather quickly lead to burns, and there is no way that healthy tissue would not get damaged.
    1 point
  5. Since this is a UK adaptor, I would expect it to be fused. That would stop it drawing a current that was unsafely high. The lowest fuse setting in the UK typically is 5 amps and the highest 13amps. 13amps at 240V corresponds (W =Vi) to 3kW - enough for a powerful electric fire or kettle. If your blanket is drawing no more than 60W each side then the combination is 120W which draws a current of 0.5 amps. This is equivalent to 2 bedside lights and is well within any safety limit - and any fuse that may be fitted in the adaptor.
    1 point
  6. New data about how deeply police killings in the US have been undercounted for decades. Source here: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01609-3/fulltext Summary: A core message here: “Currently, the same government responsible for this violence is also responsible for reporting on it,” and that's an obvious conflict of interest which results in needless problems like these.
    1 point
  7. He's not exceptionally bright - probably average, and probably didn't apply himself in school, having too busy a social life. What he mostly seems is vain and overly fond of the limelight. This is the era of populist leaders - anti-intellectual, anti-elite, anti-establishment. So he's acting what he believes the Great British Public admires. (And maybe channeling DJT) BTW - What is "bad genetics" when it's not being offensive?
    1 point
  8. Ok so now the argument is that some media outlets have not been fact checking and therefore we should take medication before they go through large trials and getting reviewed? Look, if you move the goalposts further I am going to need a better telescope. Edit, also it seems that the articles now include the comment from the NHS, so basically quoting each of the folks involved, which seems to conform to usual standards. Does it mean I should take half the dose? Or do I need to mix it with another experimental drug until the internet hypes up something else (i really hope it coffee). Edit 2, just to be as sure: don't self medicate with drugs. Ask a MD not the internet. The internet is dumb.
    1 point
  9. You speak with the tongue of oracle. I am unworthy to gainsay an oracle.
    -1 points
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