marekc

Dear CharonY, thank you for that idea with developing ELISA.

I observed that in case of treatment patient with betalactam antibiotics (e.g. penicillin, amoxicillin etc.) infection caused by bacteria resistant to them, the given antibiotic usually is not present in patient’s urine (usually 70-80% of the given antibiotic dose is eliminated by kidneys). I think that it may be caused by the mechanism of resistance to betalactam antibiotic, which rely on the production of betalactamases, which destroys given antibiotic. I think that it would be possible to develop fast and cheap test (method?) for evaluation of antibiotic resistance based on the detection of the given antibiotic in urine. Antibiotics might be detected e.g. by immunoenzymatic strip tests. In case of bacterial resistance antibiotic is not detected/not present in urine. What is your opinion about such an idea? Is there any chance to develop it? Or there is only a wishful thinking? I am sorry for some of the inappropriate phrases, I am a family doctor not a microbiologist. Thank you in advance for your help.