Alright so yes, I take this for acne...
Swanson-t: I would say that the placebo effect is not in play here. I say this because prior to using this treatment, I tried many other things, either prescribed by a doctor or not, and my mindset was the same upon trying each one: hopeful that it would work. None of them ever did except this one.
Hypervalent: The only scientific literature I've ever found on this, and the reason I actually started this treatment, is based on research done by Dr. Leung. His findings were actually pretty interesting. I've also read about the side effects you mention, but have not personally experienced any of those (or any others). But different people respond to things differently. I've also read that it is temporary, but I've been using it for 7 years and it still works for me. I think there is a lot of misinformation out there on the subject, because a lot of people don't do it properly (for example, once their acne goes away, they will do a "maintenance dose", which involves taking less pills, and it just doesn't work). Also, anti-acne is a huge business and I'm sure Proactiv, Clearasil, and Accutane don't want you to know that their products are BS and you can get rid of acne for $25 a month.
I see why you may feel that this endeavor is pointless, but while I don't necessarily mind swallowing the pills, its a pain in the buns to always be planning ahead, travelling with the pills all the time, and always remembering to take them every 4-5 hours.
As far as my vision for an alternative, that's why I posed the question here! It would just be great to take less pills less often, or having something in a liquid form. But its tricky because its such a high dose. I guess I'm just wondering if there is a way to have a super concentrated vitamin delivery system.
Phi- I think you are on the right track here. There are a lot of questions out there that don't have answers. Very frustrating for acne sufferers. My theory: People break down the fats and oils from the food we eat differently. For some people, all the excess fats and oils turns into fat stored on the body easier than for others. There are people like me who don't get fat, but break out with acne. Some people get both, and some people just handle it a lot more efficiently and don't get fat very easily and dont break out ever. I don't know what the exact mechanism is, but I believe that B5 is helping my body process the fats and oils from food better. When I'm not on the B5, my skin and hair is actually oilier to the touch than when I'm using it. The change is significant.