Well, as a clinical neurosciences practioner for some decades, Classification of psychiatric disorders found in the DSM5, which came out May 2013, is hardly artificial. It refers to real, scientifically measurable characteristics of, for example, narcissists. There is a Narcissistic scale in some psych tests, too. It's a real, existing disorder, and the classification of this refers to actual, existing persons who show those characteristics.
A great many public people, often in the entertainment and other professional fields are rather narcissistic. One of think of the divas who have been that way and some surgeons, to be sure.
Read the DSM classification. It's a real and existing description of these persons. If this is artificial, which most psych professionals would not agree with, then is animal ethology, which describes species behaviors and characteristics real, existing events, or are they artificial too?
These personality disorder descriptions are very carefully arrived at supported by the full panoply of published psychological/psychiatric studies and work to substantiate it.
http://www.psi.uba.ar/academica/carrerasdegrado/psicologia/sitios_catedras/practicas_profesionales/820_clinica_tr_personalidad_psicosis/material/dsm.pdf
" I don't expect you to accept this, so give me three examples of great inventors or geniuses who were thought to be stupid."
Or crazy. Semmelweiss and puerperal fever, Wegener and continental drift, and Tesla, come immediately to mind. The geologist who pointed out that the Scablands of eastern Washington were due to repeated, massive floods. There are many more. Newton believed in witchcraft, alchemy, and had some other rather weird beliefs. Today, he'd be thought of as nuts, clinically.. Recently there have been studies which show that the dopamine profiles of many highly creative persons closely resembles that of schizophrenics. There is a clear relationship between madness and genius, surely not in every case, but in too many cases to ignore.
Paul Gauguin, a number of ancient Greeks, who were quite creative, even brilliant. Socrates was killed and Galileo locked up.
As Bohr stated to a grad student, after he'd just presented a new model in physics, "Young man, your ideas are crazy, but not crazy enough to be right."
Yes, even Darwin was thought to be way out of line by a great many persons. And recall that even Einstein NEVER got a Nobel Prize for relativity, either, his greatest work.
Maybe it just depends upon POV, tho, what is crazy, what is genius, and who are stupid or fools? The Clermont and Fulton come to mind as do the horseless carriages. There are an unlimited number of examples, sadly.
"Progress in physics proceeds funeral by funeral" --Albert Einstein