Koni

Until now there is NO evidence that my 2 "Triple-Bases" or my "TRIPLE Helix DNA" exist in Natur !!!... It exist only in my Mind !!!... (sorry !!!...) And the Question is NOT if Life could choose only one "orientation" of the "Double-Bases" !!!... The Question is ... HOW could Life make it ???...

This is our "DOUBLE Helix DNA" on Earth !!!... From the "theoretical" possible 6 pairs with 12 Bases ... it has only 2 pairs with 4 Bases !!!.. On other extraterrestial Planets with Life ... they will have probably a "Double Helix DNA" with 1-6 pairs of DNA-Bases !!!... My IDEA of a "TRIPLE Helix DNA" is only "theoretical" and "hypothetical" !!!... But with "Chemical Synthetic Biology" ... we could make my 2 "Triple-Bases" and a "TRIPLE Helix DNA" to see if it is possible to exist !!!... ( Life finds always a way to make incredible things !!!... )

The NAMES of my 6 "Double-Bases": FAA = Federal Aviation Administration BBC = British Broadcasting Corporation DCE = Data Center Ethernet LDG = Latitudinal Diversity Gradient HEI = Hawaiian Electric Industries JFK = John Fitzgerald Kennedy

All the possible "combinations" to form a "Triple-Base" !!!...

Into the YELLOW-Circles are the "tautomeric Hydrogens" and the one circle can change into the other circle !!!... The YELLOW-atom is a charged (Blue) Nitrogen(N+) atom and has a Bond with a Hydrogen !!!... But I have seen that the "opposite" Nitrogen atom can be charged too !!!... and then the Hydrogen will go to the other side of the "Hydrogen Bond" !!!... I have calculated these changes of the "combinations" of the "Hydrogen Bonds" and they cannot make other "Triplets" with the other Bases !!!... ( Only 2 "Triple-Bases" are possible !!!... )

How can Life choose only one orientation ???....

Like these scientific Ideas !!!...

Hello !!!... What do you mean ???... My IDEA of size-expanded triple-Bases has nothing to fear against the other IDEAS of the scientists !!!... Only that my "triple-Bases" can be part of a "Triple DNA Helix" !!!... Do you know how can my "Double-Bases" have always the same direction ???... ( THAT would be Helpful !!!...) THANK You for any Help !!!...

one "artistic" view of my 2 "Triple-Bases" !!!...

I have forgot to look for the "combinations" of : B-F1, B-F2 & E-C1, E-C2 ... but they can NOT make "Triple Bases" with the 6 Bases and their 4 "tautomeric" Bases !!!... Koni

a "Double-Base" of a "TRIPLE DNA Helix" can bind to 2 simple Bases of a "DOUBLE DNA Helix" !!!...

Each "Double-Base" ... is part of a "Triple Bases" ... which are part of a "TRIPLE Helix DNA" !!!... and must have always the same orientation !!!... ( So ... that if you now the "Double-Base" of the ONE Helix ... you should now the other 2 Bases of the other 2 Helices !!!... and to do that you have to know the orientation of the "Double-Base" !!!... )

The Base( AB or BA ) is part of "Triple Bases" - which are part of a "TRIPLE Helix DNA" ... How can the Base have only one specific orientation ???... ( or AB - or BA ) but NOT both !!!...

How can We -(or Life)- know ... which side of this "Double-Base": (AB) ... ... is Left - or Right ???...

The "Aliens" are coming !!!... Keep the children save !!!...

My 2 "Triple-Bases" : (FA≡BC≡DE≡FA) = (A1≡B≡C1≡A1) or (A2≡B≡C2≡A2) (LG≡HI≡JK≡LG) = (D1≡E≡F1≡D1) or (D2≡E≡F2≡D2) don't make other "Triplets" - except the "tautomeric" ones !!!...

The QUESTION is ... how can Natur (or Humans) ... make a "TRIPLE Helix DNA" where the 6 "Double-Bases" take only ONE specific orientation ???...

From my Chessboard with the <HEXAGONS> for 3 players … I had the Idea of “TRIPLE DNA Bases” : First … I had the Idea of the dark-blue Shape … with the 3 Bases: (X=Y=Z=X) with 2 Hydrogen Bonds(=) between each two Bases… Second … I had the Idea of the light-blue Shape … with the 3 Bases: (FA≡BC≡DE≡FA) with 3 Hydrogen Bonds(≡) between each two Bases… And at the END … I had the Idea of “both together” !!!... ( where “=” and “≡” are the 2-3 Hydrogen Bonds ) – ( and the small Circles o are the Hydrogens ) On these "small" TRIPLE Bases ... the up-Base is "supplementary" with itself !!!... and then 3 Bases of the same Base ... can make ONE "Triplet" !!!... On these "small" TRIPLE Bases ... the up-Base is "symmetrical" with itself !!!... and then you don't know which of the other 2 Bases is Left - or Right !!!... On these "medium" TRIPLE Bases ... the inside Red-Oxygens repel each other !!!... These are my First TWO "Triple Bases" FA≡BC≡DE≡FA & LG=HI≡JK≡LG !!!... These are the 2 “triple Bases” with opposite “Hydrogen Bonds” : (A≡B≡C≡A) & (D≡E≡F≡D) And these 2 Images shows that they can form “triple-Bases” with the Help of the Bases: { X,Y,Z }: First Image = ADX & BEY & CFZ Second Image = ADY & BEZ & CFX The 3 Bases { X,Y,Z } can form – from alone – “triple-Bases”: XXX & YYY & ZZZ !!!... This was my first “perfect” design !!!... – of 2 “Triple DNA Bases” !!!... ( The “Hydrogen Bonds” from the left Triplet are “the opposite” to the “Hydrogen Bonds” from the right Triplet !!!...) ( The YELLOW and BLUE and RED Bases … have the same “molecular formula” !!!...) IF you turn the Level of the right Triplet 180o … the colored Hexagons with the Letters … of the right Triplet … would take the same position … as the colored Hexagons with the Letters … of the left Triplet !!!... AFTER the turn … of the right Triplet (with the small Black Letters) … … I had the problem of “tautomerism” of the blue and green Hydrogens !!!... … and instead of 2 “Triple Bases” … … I was left with only ONE tautomeric “Triple Bases” !!!... To overcome this problem … I have designed again my 2 “Triple Bases” … … including the tautomerism of the Hydrogens into my Design !!!... ( the green and blue Circles ) !!!... This is my “final” Design of 2 “Triple DNA Bases” : ( FA≡BC≡DE≡FA ) & ( LG≡HI≡JL≡LG ) !!!... ( one Nitrogen is charged ) – (N+) ( 1=Hydrogen ) These are the 10 “tautomeric” Bases !!!... which can be used by an (Alien) “TRIPLE Helix DNA” because: NO Base is "supplementary" with itself !!!... because then 3 Bases of the same Base ... can make ONE "Triplet" !!!... NO Base is "symmetrical" with itself !!!... because then you don't know which of the other 2 Bases is Left - or Right !!!... The 6 (10) Bases of the 2 Triplets … cannot make other Triplets with other "combinations" !!!... except their “tautomeric”!!!... ( image / right ) the charged Nitrogen(N+) is YELLOW !!!... and the “tautomeric” Hydrogens are those with the purple-Bonds !!!... ( The grey-Bonds are simple-Bonds(-) … the red-Bonds are double-Bonds(=) … the yellow-Bonds are simple tautomeric Bonds … and the charged Nitrogen(N+) is RED !!!... After the turn of the right "Triple Bases" 120 degrees to the right (like the clock) ... you can see that the 3 Bases of the left-triplet are "similar" to the 3 Bases of the right-triplet !!!... ( With YELLOW-Circles I show the replaces between Black-Carbon atoms and Blue-Nitrogen atoms !!! ) Life don't make TWO different "Triple-Bases" per Luck !!!... Life makes First the ONE "Triple Bases" and then ... change them ... through EVOLUTION ... and makes the second "Triple Bases" !!!... The two(2) up-levels are the “DOUBLE Helix DNA” with the Double-Bases: G≡C & A=T … The two(2) down-levels are my “TRIPLE Helix DNA” with the Triple-Bases: FA≡BC≡DE≡FA & LG=HI≡JK≡LG !!!... ( The radius of the Double Helix is = 2/3 of the radius of the Triple Helix !!!...) When you have (3/3)DNA Bases...then: Or m-RNA = (1/3)Bases and t-RNA = (2/3)Bases Or m-RNA = (2/3)Bases and t-RNA = (1/3)Bases Or both !!!... The problem: IF you have ONE Helix … of the THREE DNA Helices … … you have not only to know the Bases of the Helix !!!... … but you need also to know the “orientation” of each Base !!!... … so that You can know which Base is on the other TWO Helices !!!... I have add to the one external side of each “double-Base” a Methyl group (-CH3) !!! ( I do NOT know … how this could Help !!!...) Have you any Idea to this problem ???... THANK You very-very much my friend for any Help !!!... Kosta: “Have a nice Day – EVERY Day of your Life !!!...”

On this Image ... I have turned the right "Triplet" 120 degrees to the right (like the Clock) ... Now you can see ... that the 3 Bases of the Left-Triplet are "similar" to the 3 Bases of the Right-Triplet !!!... The YELLOW Circles ... show the changes !!!.... ( between Black-Carbon atoms and Blue-Nitrogen atoms ) Life don't make by "Luck" two different "Triple Bases" !!!... Life makes First the ONE "Triple Base" ... and then thru Evolution ... change it !!!... to make the second "Triple-Base" !!!...

( The grey-Bonds are simple-Bonds(-) … the red-Bonds are double-Bonds(=) … the yellow-Bonds are simple tautomeric Bonds … and the charged Nitrogen(N+) is RED !!!... the charged Nitrogen(N+) is YELLOW !!!... and the “tautomeric” Hydrogens are those with the purple-Bonds !!!... The problem: IF you have ONE Helix … of the THREE DNA Helices … … you have not only to know the Bases of the Helix !!!... … but you need also to know the “orientation” of each Base !!!... … so that You can know which Base is on the other TWO Helices !!!... I have add to the one external side of each “double-Base” a Methyl group (-CH3) !!! ( I do NOT know … how this could Help !!!...) Have you any Idea to this problem ???... The QUESTION is ... how can Natur (or Humans) ... make a "TRIPLE Helix DNA" where the 6 "Double-Bases" take only ONE specific orientation ???...

IF you have TWO "Triple DNA Bases" ... that they can be used by a "TRIPLE Helix DNA" ... they must: (1) The 6 Bases of the TWO "Triple DNA Bases" ... must only make these TWO "Triplets" - and NOT other "combinations" !!!... (2) Each Base does NOT be "supplementary" with herself !!!... because then 3 Bases of the same Base ... can make ONE "Triplet" !!!... (3) Each Base does NOT be "symmetrical" with herself !!!... because then you don't know which of the other 2 Bases is Left - or Right !!!... I went back to my older design ... with the charged Nitrogen(N+) atom ... ( the YELLOW ) ... and now my 2 "Triple Bases" can be used in a "Triple DNA Helix" !!!... Kosta - GREECE - 11/8/2019

IF you have TWO "Triple DNA Bases" ... that they can be used by a "TRIPLE Helix DNA" ... they must: (1) The 6 Bases of the TWO "Triple DNA Bases" ... must only make these TWO "Triplets" - and NOT other "combinations" !!!... (2) Each Base does NOT be "supplementary" with herself !!!... because then 3 Bases of the same Base ... can make ONE "Triplet" !!!... (3) Each Base does NOT be "symmetrical" with herself !!!... because then you don't know which of the other 2 Bases is Left - or Right !!!... This is my last Design with the 6 Bases ... of the TWO "Triple Bases" ABC & DEF ... with 5 "tautomeric" Hydrogens ( the YELLOWS !!! ) These are the 12 "tautomeric" Bases ... from the 2 "Triple Bases" : ABC & DEF !!!... The Base "D2" is "symmetrical" with herself !!!... and ... can make with the Bases: ( E & F2 ) ... ONE "Triplet" !!!... This is the "dead end" of my IDEA ... of a "TRIPLE Helix DNA" !!! Kosta - GREECE - 11/8/2019

If you have an Alien "Triple DNA Helix" ... the DNA = (3/3)Bases ... and then: or m-RNA = (1/3)Bases and t-RNA = (2/3)Bases or m-RNA = (2/3)Bases and t-RNA = (1/3)Bases or you have "both together" !!!... ( with 2 m-RNA and 2 t-RNA and 2 different Ribosomes) a little "crazy" to be true !!!...

The one YELLOW square ... can change ... to the other YELLOW square ... with "tautomerism" of the Hydrogens !!!...