I'm really enjoying the MaddAdam trilogy by Margarett Atwood. When I have time for it.
It's a great look at how the world may come to be after we obtain the ability to create our own organisms through gene splicing.
Ultimately a plague is our ultimate demise. It is induced by an intelligent man who creates his own species of humans and decides that the old version needs to be eliminated in order for his new version to survive. So he makes a "sexual performance enhancing" pill to sell and induce the plague to kill us off. Some of us do survive though and this is mostly about the aftermath.