Hello.
Having in mind that this is my first post here, I'd like to say hello to everyone on this site.
My name is Krzysiek, I'm 21 and currently studying first year of medicine.
Right now I'm preparing for my first biochemistry exam.
I'm using "Harper's Biochemistry", but the author's language ain't making it easy to understand This is the only paragraph that mentions the acid-base catalysis:
"Acid-base catalysis can be either specific
or general. By "specific" we mean only
protons (H3O+) or OH- ions. In specific
acid or specific base catalysis, the rate
of reaction is sensitive to changes
in the concentration of protons but
independent of the concentrations of other
acids (proton donors) or bases (proton acceptors)
present in solution or at the active site.
Reactions whose rates are responsive to all the
acids or bases present are said to be
subject to general acid or general base catalysis."
For me it is so unclear!
So, as far as I know only the H+ and OH- ions decide whether a particular compound is acidic or not. So how come "the rate of reaction is sensitive to changes in the concentration of protons but independent of the concentrations of other acids"? If there are other acids in the solution automatically the concentration of H+ ions increases and this is what the "specific" mechanism is sensitive to. I mean, in my opinion the presence of other acids induces the change of H+ concentration, so it's impossible that the "specific" catalysis won't be affected...
Can someone please put this Harper's paragraph in a simpler language with regards to my reflections? Thanks in advance