It's all about questioning assumptions. If you're going to start with one "primary" assumption, which would logically lead to a hole chain of them, the reasons for deciding the nature of each link in the chain should be questioned just as much as the first link.
Premise 1: The Universe is a simulation. A) Accept the premise. B) Question the premise. If (A), goto Premise 2.
Premise 2: The simulation was programmed by one single person. A) Accept the premise. B) Question the premise. If (A), goto Premise 3.
Premise 3: The programmer is male. A) Accept the premise. B) Question the premise. If (A), goto Premise 4.
...And so on.
I do like the whole concept of procedural generation. I think that's basically what the Mathematics is/are to physics.