Aaron1991

Thanks for the replies! I don't need to know too much about the actual brain areas thought. I'm really just having trouble focusing my essay atm. I've written about Huntington's - CAG repeat expansion, protein aggregation/accumulation, and how aggregated disrupt UPS function (not sure how), allowing the aggregates to build up and damage or kill the cell. However, Parkinson's is confusing me. Is the UPS even involved here? Where do Lewy bodies even come from? I know in Huntington's the aggregates come from the overly long htt proteins being cut up into filaments, which then all accumulate into one. With Parkinson's however, I can't find much on where these inclusions come from. (wrote this really fast, so hope it makes sense)

Hey! So I've to write a 2000 word essay on the similarities and differences between Huntington's and Parkinson's regarding 'molecular pathology'. However, I've driving myself mad trying to understand this - given that there is so much information out there on these two disorders. I know I've to at least talk about the genes involved, CAG repeats, and Ubiquitin. Can anyone explain briefly to me where the difference and similarities actually lie between these disorders? Thanks