fredreload

Sir, thanks for the grammer correction :D. All hands on British tea :D.

Woh there, I did not invent alcohol lol, but I just thought maybe the inventor would know that it could be used as a drug before penicillin shows up? No offense Alexander Fleming, I respect you.

If you've ever been on a commercial airplane, the buckle sign lights up before the airplane goes through heavy wind that would drift the airplane ups and downs. And so the aircraft must have a way of predicting the wind current. I want a way to travel faster on a commercial flight, but you know you need all things in check including airplane integrity. You could have a magnetic field to filter out the air turbulence, but then you'll have to work on traveling counter to the earth's magnetic field instead of air.

Once every two weeks on 3% alcohol = =, don't worry I got a good liver .

So a few days ago I started drinking alcohol, the 3% alcohol cocktail by Suntory that is sold in the market. After continuously drinking for a month, I have not caught a cold since. And there really isn't any other symptoms besides no longer afraid of heat and sneezes from time to time, it probably killed too many germs. Anyway, there was this myth that drinking eggnog cures cold. So, this is unconfirmed medical advice, meaning you shouldn't try it when you are sick. If the cold is not going to kill me I might experiment with the cold by drinking that 3% alcohol. But I want to hear what you experts think. I mean drinking alcohol goes into the whole body and bloodstream instead of just rubbing it on the skin, but at low concentration that is. I dunno if that amount of concentration is good enough to have therapeutic effect in killing bacteria and viruses.

Does the aircraft has a laser scanning obstacle detection system? I mean I know the aircraft has a way of checking the turbulence, but I am not sure how it does it. If there is a video about this please show it to me, thanks.

P.S. a one to one clone*

Precisely, an exact clone would also have a consciousness region developed at birth. I speculate that the consciousness region remain static so it should be an exact match to my current self at age 33 because consciousness remain the same since birth but with a different set of memory as I age, I do not become a different person's consciousness when I turn 2, as an example, (whether the consciousness region remain static is debatable). Though it is more fun if my consciousness can be transferred into another person's brain's consciousness region.

P.S. Can I get some professionals comment = =, like from the dream groups

You've probably read my other post below. And here focuses on the idea of optogenetics. To being with, I will post a video on the introduction of optogenetics. Now this baby only activates or deactivates neurons. The real work for our focus lies in modify the dendrites and the synapses, therefore we could change the rhodopsin structure to match our needs. The video below shows the structure of the rhodopsin channel. So by modifying the G receptor, we will introduce 4 pathways. One pathway increases the number of dendrites, one pathway decreases the number of dendrites, one pathway uses glutamate to modify activation of the synapse, and one pathway uses GABA to modify the inhibition of the synapse. The ultimate goal here is to create a clone similar to me and match the brain stem thereby allowing me to transfer my consciousness over. Feel free to post and theorize whether my idea is correct or not.

1. Well yes I don't mean memory formation, I mean how the brain/consciousness interprets memory(through dendrite number, length and synaptic delays). You've proven me that both dendrite and synapses can affect RNA, which is quite valuable information. 2. If I am to remap the entire brain's nervous system. I would, run a still unknown pathway(unknown pathway to myself) to change the number and length of dendrites. Then I would run a pathway on glutamate/GABA to create synapses on the already existing dendrites. If I am to rewire someone's brain to match mine. If you got more to add feel free to let me know. P.S. I dunno about increasing or decreasing number of neurons to match my brain though, I think female generally have a smaller number of neurons than male. Fred

Sir, 1. Well in this regard we sort of have to understand consciousness and that which affect memory as a whole. Consciousness as I see it is an electrical resonance that occurs within the brain. To skip over all the complex theory I ask what could possibly affect a memory in a brain. The answer would be "dendrite numbers, dendrite length, and synaptic delays". I don't think axon length has any affect on memory, it could. So the snail's memory is changed by the RNA, and since the memory is changed it must affect "dendrite numbers, dendrite length, or synaptic delays". Synapses is built dynamically as I see it from glutamate or GABA receptors, therefore it must not be affected by RNA. What is left would be "dendrite number and dendrite length" that could be changed in this case. 2. Well the dendritic build is either dynamic or affected by DNA. If I have to remap the dendrite on a neuron I will either have to "cut the dendrite" or "change the RNA/gene expression". I just want to be precise in this regard. Sincerely, Fred

Sir, Hi, I will answer the above questions. 1. The dendrites should be modified because they inject RNA into the sea snail's brain(RNA->change gene expression in cell), which is likely to modify the gene expression and epigenetics of the neurons. They however, went on to speculate that the nucleus is doing the work in which they did not examine the changes in dendritic wiring. The proof I want is that RNA modifies dendritic wirings because of epigenetics, that way you can change the number/length of dendrites through different pathways. The article is posted below. https://www.sciencealert.com/memory-transferred-between-sea-snails-rna-engram 2. Well this article I found suggested that the dendrites grew back after they cut it off in drosphila neurons(sorry I can only find drosphila example). The article says that there is a different regeneration pathway for axon and dendrites, but this is not the point I want to prove. The dendrites regenerate suggesting that the epigenetics keep a backup of the structure of the dendrite's length and numbers. Of course the dendrite could have as well grew back anew from the neuron, but they used the term regenerate, and I am unsure on the time frame it took for growth vs regeneration as well. I read a few years ago that the epigenetics supposed to hold a record of the length and numbers of the dendrites, but I've long since lost that paper. Epigenetics is more of a new field for me, I interpret it as a different way of gene expression. Below is the article for dendrite regeneration. https://www.sciencedirect.com/science/article/pii/S2211124713007675 P.S. My eventual goal is to use optogenetics/pathways to remap the entire brain, dendrites and synapses.

Well, I try to find the best solution on Google, but there are all kinds of saying and research including epigenetics, and the research on ncbl which is technical yet complex at the time. It is a bit hard for me to just find a research on such as if epigenetics determine the number of dendrites presented on a neuron. The closest I found is RNA modification in the brain on Sea Snails. Which in terms should modify the dendrites because the sea snail's behavior changes, but they did not go over dendritic changes at all. I did find and is pretty sure on the synapse formation from Glutamate or GABA signaling. So the only thing I am unsure on is the dendritic growth which has been clarified thanks to you else I would probably have to go over the sea snail article again( I can't believe they did not analyze the dendritic patterns afterward). And as a record it does seem like the neuron's DNA holds a record of the dendrites because the dendrites, once cut, could easily be regenerated.

Good call, the neuron does generates its own electrical signal due to ion imbalance when it is just born and is not connected to other neurons. I speculate.

Hmm, I think the dynamic process is correct about dendritic growth, but when the embryo first form, does the dendrite randomly branch out in all directions from a neuron? Why does it branch out 5 dendrites instead of 4 dendrites, what is governing this? This is an image example https://sapienlabs.co/dendrite-complexity-and-intelligence/

I'm thinking of two pathways. One that increase the number of dendrites on a neuron, and another decrease the dendrites on the neuron. I mean you don't just stick a gum onto a neuron to form a new dendrite. The neuron comes with a fixed number of dendrites and it is up to the gene expression to change the number of dendrites it branch out from the neuron. Now when dendrites touch each other, it form synapses. I am not sure if my speculation is correct but do verify this for me Strange. Thanks in advance.

It is alright, thank you for taking the time to read my response. I understand the rigidity of science and thank you for your patience . Sincerely, fredreload

Hi sir, the only reason I look into the genetics of the brain is because I am curious about swapping consciousness. This might be a bit jumping the gun as it is way ahead of the topic, but I find that you sir, might have the knowledge to interpret such a thing. To begin with, our consciousness stays with us throughout our life. And as we fall asleep, the nerve electrical signals retract to the brain stem in a hibernation state. Therefore, I conclude that the consciousness region of the brain must exist inside the brain stem, based on a scientific paper, which sort of rules out the entire cerebellum. Now, to go one step further, let's take a look at the brain stem. A brain stem consists of multiple nucleus form from groups of neurons. The nucleus, from my speculation, resembles that of a ping pong ball. And it is from the repeating rhythm of the nerve signals running within this ping pong ball that generates a soul, a consciousness. Watch the video below to get a sense of rhythm based on the brain wave. Now we all know that a nerve signal running in the neurons generates an electric field like a capacitor because of the opposite polarity of sodium and potassium inside and outside the neuron. This means this ping pong ball of consciousness has an electric field emanating out in all directions like a light bulb. Now, what distinguishes a consciousness from another and makes it unique? If you look at the ping pong balls, they all look the same, but clearly they are of different consciousnesses, therefore I must rule out the possibility that the shape of the nucleus(group of neurons) of ping pong ball is the key to the uniqueness of consciousnesses. This means someone could have a cylinder nucleus head or pyramid nucleus head, no I ruled all that out. (But I have to note that the shape of the brain might have an implication on the generation of the resonance of consciousness, the shape of the brain might not constitute the uniqueness of the consciousness, but it does matter on constructing a consciousness). Then what is the difference between the two ping pong balls of consciousnesses. Based on the property left of a neuron, it must be the axon length and the synaptic delays. Since you have just ruled out the idea of axon length, based on the nerve signal traveling speed of 150m/s the distance of axons should be of marginal differences to consider. That leaves the rhythm, the synaptic delays as the key to the uniqueness of consciousnesses. Now could two neurons coming from two different genetics generate the same synaptic delays. This would be the key to mind uploading as you match the rhythm from one brain to the next. Clearly if it is of an identical clone or twin of same genetics I could match the synaptic delays with ease. But if you cross reference it to a different individual, could the same synaptic delays be built on the neurons thereby matching the rhythm of two ping pong balls and consciousnesses?

Well let's compare a single neuron. The axon length is mostly the same for the two I speculate, or does it differ between male and female? Can you also get the same synaptic delays for the two neurons for male and female(i.e. the delay time traveling from neuron to neuron).

Yes master, right because everyone's genetic is slightly different based on height and size, but that shouldn't affect the cells being the building block of the body, maybe the pigment. Of course to prove whether you could get the exact same synapses of two neuronal cells with different genetics is still in debate. But if synapse is an attribute of the neuronal cell type, it should hold true unaffected by the genetics. I am not sure about pigments though, as it constitute different eye colors and hair

Question: Person A and Person B has different DNA. If you are to match person A's neurons and synapses with person B's neurons in structure and synaptic delays is it possible?

Ranging from dinosaur to your neighbor, what is the DNA samples you wish to get your hand on? 1. Myself 2. My mom 3. My cat 4. My neighbor

Alright, enough joking. There are two types of mutations. 1. For muscle dystrophy or color blindness because of a single letter genetic mutation. Sometimes they send in the crispr to fix that one single letter for proper enzyme production. What I assume is that once the letter is switched, the correct enzyme begins to produce without having to proliferate(regeneration). 2. This is from speculation(I guess it really doesn't belong here = =). If I swap all the chromosomes in my body with the bear's chromosome, which is considered a mutation. Do all the cells in my body gets converted to bear cells automatically? Do the cell's identity changes because I swap the chromosomes in the nucleus? Human cell + bear chromsomes in the nucleus = bear cell? P.S. I think it is possible, question answered, thanks

We've all seen x-man right? What's the chance of that happening Charon?