Elias Jeryes

thank you Professor S. Laureys for your reply, and yes I know about absolute refractory period ( in which any stimulus no matter how strong it is, it won't cause an action potential) and the relative refractory period ( in which depolarizing is possible but only with a stronger stimulus) and thank you for your help :)

Hello everyone, I'm a medicine student and i have final exam in general physiology, one of the topics in the course is Action Potential, I can say i understand the action potential pretty well, but I have something to ask about which i still don't know. As action potential develops from supratheshold local depolarization, sodium influx depolarizes the membrane until the inactivation gate of the voltage-gated sodium channel is closed at the peak of the diagram, and so on the membrane at this stage can't be depolarized again until the voltage-gated sodium channel retains its original configuration in which the activation gate is closed and the inactivation gate is opened, well, my question is : when does the voltage-gated sodium channel retains its original ( or resting) configuration after the peak on the diagram ? and thank you for your cooperation