YuvalKon

Well, your first comment was all about how I use the definition wrong, without even trying to explain yourself, so I can't see any helping with leaving a comment that says "You are wrong". Thanks for the definition tho, but it's still not clear to me how the PKa is effected from the electronegativity.

I don't need electrostatics in high level, just some principles in biochemistry. I didn't say all amino acids, the question is about positive charge amino acids (those that have epsilon amino in the R group), my definitions might be a little wrong but I think I'm clear. And I'm here to understand things better, and not for someone to tell me how wrong I am, so thanks for nothing. If anyone else could explain this to me I would be very thankful

Hey everyone, my question is, what makes the different in PKa of alpha amino and epsilon amino in amino acids? My teacher wrote to us that alpha amino is near the carboxyl group, and the O is electronegative so it want to gain an electron, but I don't get how this thing makes the amino group near the alpha carbon to want to lose a proton? Thanks