That would certainly be funny. Not everyone who would play the game is over 18 and I don't drink myself so something with ethanol would quickly exclude people. Although it could be something with capsaicin in it...
I guess that would need some preparation every time. I would prefer to keep things simple. But I will remember it in case people would actually want try it.
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The kind of thing I would need to make the original idea workable would be a kind of index of chemical substances from which I could randomly choose one and ask questions about chemical and physical properties, history, accidents that the compound has been involved with and lots of other trivia.