Hello everyone,
So, there are two different theories (Somatic Mutation Theory and Tissue Organization Field Theory) that supports the explanation of cancer. I would like to find out how these theories relate to each hallmark of cancer (mainly sustained chronic proliferation, evading growth suppressors, resisting cell death, enabling replicative immortality, activating invasion and metastasis, inducing angiogenesis, avoiding immune destructions, deregulating cellular energetics).
For example, would evading growth suppressors be supported by SMT or TOFT? On one hand, there could be mutations which results in the change of expression of tumour suppressors which causes the cancer (supporting SMT), on the other hand, it could have been the result of loss of cell-cell contact inhibition, resulting in the proliferation and formation of the tumour.
Is it possible for one hallmark to support both theories, or am I not understanding the two theories correctly.
Please help!
