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Hello John, thank you for your reply! The study is actually designed to mimic the biological system. Some water will be removed in regular intervals and replaced. I'm quite sure that the hydroxyapatite is more or less insoluble both in vitro and in vivo, even though it might lose its structural integrity and turn into a paste (has been seen in vivo). I just need to make sure that the calcium sulphate wont make any precipitation that might damage the measuring equipment. Also any thoughts on iohexol and salt water? Cheers

Hello, I'm trying to design a small analysis of a synthetic bone mass substitute. Its according to product descriptions made of 40% hydroxyapatite and 60% calcium sulphate of which the Calcium Sulphate is meant to slowly wash out in order for new bone to grow in. The synthetic bone also has some added iohexol for radio opacity. 1 mL of hardened mass will be placed in 5 mL isotonic NaCl. The idea is to analyse how much Calcium concentration rises over time in order to determine how fast the Ca Sulphate fase is washed out. Will hydroxyapatite or Calcium make bonds with Cloride? How much can I expect the Calcium concentration to change in 37 celcius? Will the pH rise? I know the description is a bit lacking. I'm just looking for some pointers or advice. Thanks in advance!