jonnyc55

That is very interesting and good to know. I will look into these functions. Regarding vitamin D excess effects I will definitely take note. I had been taking Vitamin D3 tables (rated at 500% NRV). Would multivitamin tablets with D3 at 100% NRV prove better? Also is there any other way to promote metabolism of aripiprazole? Or to give further aid to enzymes such as CYP3A4 and CYP2D6? Thank you.

So I've seen this from wiki: and then this: I guess the above concerns dehydro-aripiprazole, because (see below). And then this from ncbi: Aripiprazole is a lipophilic. Hmm interesting. So the metabolite becomes a more readily able object to be removed?

I thought the best place to ask my question is a Biochemistry forum :). So I have been forced to take Aripiprazole. A low dose of 5mg a day. I read that vitamin D3 is an inducer of the enzymes CYP3A4 and CYP2D6 both of which are the prime enzymes that breakdown Aripiprazole into Dehydro-Aripiprazole (an active metabolite) . Now what happens to the Dehydro-Aripiprazole? Is that broken down even more? Or is it turned into a form that can then be excreted from the body? I quote this : " Only after they are metabolized into more hydrophilic molecules, can they be excreted through the kidneys into the urine." My other question to all you biologists regards the above quote, is dehydro-Aripiprazole a hydrophilic molecule? And therefore can be then excreted? My concern is, since i have been forced to take Aripiprazole, i don't want a increase in Aripiprazole in my blood after each day or to have a horrible build up. Dehydro-aripiprazole also works a bit like the parent drug Aripiprazole. I want to make sure that dehydro-aripiprazole is flushed out and that it doesn't build up. I don't want the negative toxicity effects. Will there be an enzyme that breaks down the active metabolite dehydro-aripiprazole? Or is it now in a form that can then be excreted? (And i hope Vitamin D3 stimulates this process.) Thank you.