thank you Bad for the reply.
I have already tried DCC/DMAP in Ch2Cl2. I am still trying to find out if I succeeded or not. I am trying to make an ester from Retinoic acid with
3,5-Di-tert-butyl-4-hydroxy-benzyl alcohol (BHT-OH).
Retinoic acid is notorious in flipping around its double bound and giving up isomers. at this stage I am more interested to put A+B together and get the ester. with steglich reaction I easily get the retinoic acid react with DCC, but it seems reaction does not give the ester I am looking for. stirring the mixture overnight at RT with drying tube attached produced two compounds along with starting material. one seems to be retinoic-DMAP, the other unknown. I am monitoring the reaction using HPLC and soon I will switch to LC/MS to figure out what is going on here
many thanks for your reply
mike
