Aney

1. The procedure was refluxing the amide containing compound with paraformaldehyde until clear solution obtained, left for gentle stirring overnight, next day piperidine was added and again the mixture refluxed for several hours. Monitoring with TLC gave 2 spots as I said previously, attempts to make the product with single spot by adding more one of the reactant not successed 2. Yes, 2 distinct spots, do you think column chromatography is suitable ?

Rgarding to Mannich reaction between amide and secondary amine, I had 2 spots one matching the reactant and another is different, I have 2 question 1. The technique can be followed ? Best technique to be used in synthesis of amide-amine Mannich ? 2. Can I separate these 2 spots ?

I will go ahead to the next reaction using the same sticky mass because NMR and MS take long time to be done ..

Nice speech .. No ..

No ..

It is recommended to be solid powder, because of my fearing that impurities make it as sticky mass not powder .. O. K

it is building block for synthesis of the final products I want to make it as powder to complete my work any idea for helping ???

how to deal with sticky mass which produced during organic synthesis ?