Tiger1

Well you got me there, I was just hoping you had some input on my homework dilemma (no psuedohip avatar).

I guess the advantage of being able to design the experiment is I can take the liberty of having any results I want to as long as they support in some way the question being asked. Do you have any thoughts on that Mr. gut bacteria or are you just a terminal smart ass.

This is almost an outright plea for spoonfeeding, albeit not before 8 hours of study hasn't produced much of a clue!! Here's the question: "Using various inbred strains of mice, design an experiment to determine the importance of the three classes of MHC antigens in graft rejection. Include results and interpretation of the results in your answer" I've got a good grip on the 3 types of MHC antigens and their relative importance in rejection. Cl II being most implicated (HLA-DR) followed by Cl I (HLA-B>A>C) and trailed by Cl III which I probably need to tie involvement of complement to and the fact that Cl III is usually expressed on endothelial cells. My problem is the damned mice. Any ideas or is more info. needed?