Aconitin

Hello, I hope this answer does not come to late. I think the hypovolemic shock comes from vasodilatation and the movement of fluids to extracellular regions. So, technically, the patient doesn't lose fluids, but there is still less in his blood vessels. Greetings, Aconitin

Hello! I have a question regarding H1-antihistamines. It is said, that first generation antihistamines are used to treat nausea because they can cross the blood-brain-barrier and reach the vomiting centre. However, I read that the vomiting centre is not protected by the blood-brain-barrier. So is the ability to cross the blood-brain-barrier irrelevant for H1-antihistamines? Greetings, Aconitin

Here's my theory: The components of a perfume that smell good might be mainly lipophilic (I think essential oil are used often, and those are lipophilic). If they are sitting on your skin, they are directly exposed to influences like warmth and oxygen, causing them to break down or evaporate quite fast. If they are applied onto a lipophilic base, they can diffuse into this base and probably also partially into the skins top layer (as this is lipophilic to)?

I fear my answer might come to late for your assigment, but I will post it anyways in case you still need it or anyone else is interested in the answer. I guess the pka you got from drugbank is right, as you have to see the drug as a hydrazine, not as a amine. Hydrazine is a weaker base (and therefore a stronger acid) than ammonia because of the nitrogens -I-Effect on each other.

If you have enough material, you could try in a small "sample" solving the Vitamin E in glycerine first, then add the emulsifier and add the water phase in small portions while stirring. This is just an idea from me personally, as Vitamin E is known to be lipid soluble. Keep me updated, whether you try it and if it works.

Hello, first of all I would like to apologize if my english isn't perfect. It's not my first language and I am still struggling with some scientific terms. However, I don't find much chemistry forums in my language and I usually have lots of questions, so why not go international with them? :) I read that nitrogen can be a stereocenter if it is "fixed/locked" in a certain way. Usually this is the case for quarternary amines. However I also read that the N-1 nitrogen, the one "inside" the lactam structure of beta-lactam-antibiotics can be seen as "sort of" a stereocentre. I barely find information about this. Is there a clear answer? Or can we just say that the nitrogen inversion is reduced, but not to what extent/whether there is a stereocenter or not? Thanks for your answers in advance! Aconitin