Megatherium0

Just found an answer about the endurance of the results from partial reprogramming: https://link.springer.com/article/10.1007/s11357-021-00358-6 in "Table 1 Studies of partial epigenetic reprogramming" there is a table with experiment on partial reprogramming and the duration of their effects and in most cases the effects only lasted for several days. Now I have a different question, is there anything in this article that suggest a possible reason for why those changes doesn't last? or a way to make those changes permanent?. The article does say that partial reprogramming hold a great promise for treating aging, and it also suggest the following: "A suggestion is an approach similar to the one shown by Ocampo et al. [28], but with the inclusion of a treatment that enhances genome stability during the absence of pluripotency factor expression. Short expression of pluripotency factors followed by administration of metformin, rapamycin, or even resveratrol would slightly flip the epigenetic landscape followed by the formation of deeper grooves. Perhaps this procedure would both improve lifespan extension and hinder the development of cancer and senescent cells.". does this have anything to do with making the results of the partial reprogramming more permanent?.

Can someone explain me some studies I saw about partial reprogramming and rejuvenation?. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679279/ Multi-omic rejuvenation of human cells by maturation phase transient reprogramming - https://www.biorxiv.org/content/10.1101/2021.01.15.426786v1.full Is there anything in the first research that suggest that the rejuvenation that you get from partial reprogramming need constant maintenance(constant treatment) in order to endure? or that the results are permanent and will change only as a result of normal aging?. What the second research say about it?. And what kinds of aging related damage does partial reprogramming can reverse according to the second research?. I don't have a degree or any significant knowledge in biology so I hope someone will explain me those studies in more simple words.

Yes. There are organizations and research that focus on reversing aging. For most of the types of the aging damage we are pretty close to find a way to reverse it and even with one single treatment like Partial Reprogramming. There are many sites about this topic of longevity/rejuvenation like lifespan.io , you should also watch their page "the rejuvenation roadmap" https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/ if you are interested in the subject. Science isn't going to really extend our lifespan by making us old for more years, science will extend our lifespan by reversing aging and keeping us from ever being old in our lives. It is a common misconception that science can only make us old for longer but in fact it is easier to reverse aging than keep somebody as an old person while he lives longer than the normal lifespan.

I have no background in biology, but I am thinking about possible permanent treatments for Male Pattern Hair loss(MPHL) that are possible with current technology and I wonder if it is possible to give someone 5α-Reductase deficiency, a condition caused by a mutation in a gene encoding the enzyme 5α-reductase type 2(the main cause of MPHL) by using gene therapy. Is gene therapy like that can be in the form of an injection that can be shipped internationally?, Can it be developed with current technology?. People with 5a-Reductase deficiency do not suffer from MPHL and The only problems with this condition arise from the fact that people are born with this so their genitals don't develop normally because of it. But other than that they don't suffer from anything else and they are even fertile.