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Everything posted by Flamboyant
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Human parthenogenesis
Flamboyant replied to Flamboyant's topic in Evolution, Morphology and Exobiology
I believed tumors = death What type of tumors ? -
Human parthenogenesis
Flamboyant replied to Flamboyant's topic in Evolution, Morphology and Exobiology
How to say "Vierge Marie" with respect in english ? Virgin Mary ? -
Hello everyone, For a little while, I have been wondering about human parthenogenesis. Is it really possible ? Thanks, D. https://en.wikipedia.org/wiki/Parthenogenesis
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Surprise
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I see everyone is meaningfull. As me. As PhD's.
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http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.732.462&rep=rep1&type=pdf#page=17 WTF with light ? And WTF with our liver ? We're not so immortals. Light can kill us. Photophobia literally means "fear of light." If you have photophobia, you're not actually afraid of light, but you are very sensitive to it. The sun or bright indoor light can be uncomfortable, even painful. Photophobia isn't a condition -- it's a symptom of another problem. Migraine headaches, dry eyes, and swelling inside your eye are commonly linked to light sensitivity. It can cause pain whenever you're in bright sunlight or indoor light. You might want to blink or close your eyes. Some people also get headaches. Causes Photophobia is linked to the connection between cells in your eyes that detect light and a nerve that goes to your head. Migraines are the most common cause of light sensitivity. Up to 80% of people who get them have photophobia along with their headaches. Many of those people are light sensitive even when they don't have a headache. Other types of headaches can cause photophobia, too. People who get tension and cluster headaches also say they're uncomfortable around bright light. A few brain conditions can cause photophobia, including: Meningitis (swelling of the protective coverings of your brain and spinal cord) Serious brain injury Supranuclear palsy (a brain disorder that causes problems with balance, walking, and eye movement) Tumors in your pituitary gland Some eye diseases cause this symptom, including: Dry eye Uveitis (swelling of the inside of your eye) Keratitis (swelling of your cornea, the clear layer that covers the colored part of your eye) Iritis (swelling of the colored ring around your pupil) Cataracts (cloudy coverings over the lenses of your eyes) Corneal abrasion (a scratch on your cornea) Conjunctivitis (inflammation of the conjunctiva, the clear tissue that sits over the white part of your eye) Damage to your retina, the light-sensitive layer in the back of your eye Blepharospasm (a condition that makes your eyelids close uncontrollably) Photophobia may also affect some people who have these mental health conditions: Agoraphobia (a fear of being in public places) Anxiety Bipolar disorder Depression Panic disorder You can also get photophobia after you have LASIK or other surgery to fix vision problems. Certain wavelengths of light -- like the blue light your computer and smartphone give off -- cause the most sensitivity. Some medicines can also cause photophobia, including: Antibiotics, such as doxycycline and tetracycline. Furosemide (Lasix): This keeps your body from holding on to too much fluid. It's used to treat congestive heart failure, liver disease, kidney disease, and other conditions. Quinine (Qualaquin😞 This is a drug used to treat malaria. Diagnosis If you think you have photophobia, see your eye doctor. They'll ask about your symptoms and any medical conditions you have. Then they'll check the health of your eyes and possibly your brain. Tests your doctor might use include: Slit-lamp eye exam. They'll use a special microscope with a light to examine your eyes. MRI, or magnetic resonance imaging.This uses powerful magnets and radio waves to make detailed pictures of your eyes. Exam of the tear film. This checks the amount of tears you make to see if you have dry eyes. Treatment The best way to ease photophobia is to treat the condition or stop taking the medicine that's causing it. If you're still affected by it, tinted glasses may help. Some people have found relief from rose-colored lenses called FL-41. But tinted lenses aren't for everyone. They can make some people even more sensitive to light, so talk with your doctor about what's best for you.
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Thanks buddy. How to explain problems with light ? As you can see : https://pubmed.ncbi.nlm.nih.gov/15001238/ Immortalization of hepatic progenitor cells Anne Weber 1 Affiliations PMID: 15001238 DOI: 10.1016/j.patbio.2003.02.001 Abstract Development of cell therapy-based strategies for the treatment of liver failures and of inherited metabolic diseases has become a necessity because of the limitations of orthotopic liver transplantation, including shortage of donor livers. This shortage limits also the availability for hepatocytes and these terminally differentiated cells cannot be expanded in vitro. Thus, other alternative sources of hepatocytes have to be explored such as hepatic stem cells. Foetal hepatic cells have specific intrinsic properties compared to adult hepatocytes that should overcome some of their limitations. Thus, the availability of in vitro expandable progenitor cells by means of immortalization and without inducing a transformed phenotype and disrupting their differentiation potential would facilitate studies on cell engraftment and differentiation within the hepatic parenchyma. A temporally controlled expression of the immortalizing transgene would also permit to revert the immortalized phenotype prior to cell transplantation. Since characteristics of murine stem cells cannot readily be extrapolated to their human or other primate counterparts, we have immortalized one clone of primate hepatic progenitor cells using a retroviral vector expressing SV40 Large T flanked by lox P sites. These hepatic cells were bipotent, expressing markers of both hepatocytic and biliary lineages. After transplantation into athymic mice, approximately 50% of immortalized cells engrafted, stopped proliferating after a few days and differentiated in adult hepatocytes, suggesting that the hepatic microenvironment plays an important role in such regulations. Upon infection with a retrovirus expressing the CRE recombinase, immortalized cells stopped growing and died, showing that immortalization was dependant on SV40 Large T. These studies suggest new approaches to expand hepatic progenitor cells, analyse their fate in animal models aiming at cell therapy of hepatic diseases.
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Sorry, I don't speak, "scientific" english very well. Can a cool body explain me this ? https://pubmed.ncbi.nlm.nih.gov/11769127/ It's Gov info. And this : https://pubmed.ncbi.nlm.nih.gov/2153691/ PS : we have problems with light.
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What about https://en.wikipedia.org/wiki/Cryonics
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https://pubmed.ncbi.nlm.nih.gov/11769127/ [Immortalization of human fibroblasts using tsA mutant of SV40 and pSV3neo plasmid] [Article in Russian] L S Inozemtseva 1 , V G Chernikov, E S Manuilova, M I Marshak, N P Nikolaeva, O S Kulagina, I A Grivennikov Affiliations PMID: 11769127 Abstract Clones of immortalized human fibroblasts with an extended life span in culture and a capability of subloning were obtained after the infection with a temperature sensitive mutant (tsA 239) of SV40 virus and pSV3neo plasmid. As compared with the parental cells, the obtained clones exhibited increased plating efficiency, decreased doubling time, and serum dependence. We did not obtained the colony formation during cultivation of immortalized cells in semiliquid agar. This means that our cells were not completely malignant. The PCR (polymerase chain reaction)-analysis has revealed the presence of viral DNA at early passages (25th passage) after the infection by tsA SV40, and its absence after a prolonged cultivation (46th passage). PCR-analysis of the clones obtained after pSV3neo transfection has revealed the presence of gene A sequences either at early (9-15), or later (62) passages. The expression of the gene A product in cells of these clones was revealed only early passages (11 and 35). Possible mechanisms of immortal phenotype origin in human diploid cells after the action of ts-mutant and other constructions of SV40 are discussed.
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What the... hell ? I thought D-antigen was the problem ; never thought about T-antigen. Please, can someone explain to me the difference ? Immortality is the indefinite continuation of a person's existence, even after death. In common parlance, immortality is virtually indistinguishable from afterlife, but philosophically speaking, they are not identical. Immortality is the ability to live forever, or eternal life. ... The absence of aging would provide humans with biological immortality, but not invulnerability to death by physical trauma. Can an immortal person be killed ? Paradoxical though it might seem, biologically immortal organisms are definitely mortal. They can be killed by a predator, a disease, or a catastrophic change in the environment such as an erupting volcano. But unlike humans, they rarely die simply because they get old. Can someone explain to me why the words "rarely die" ? As if we had examples... SV40 T-antigen is required for maintenance of immortal growth in SV40-transformed human fibroblasts : https://pubmed.ncbi.nlm.nih.gov/1851674/
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https://www.collinsdictionary.com/dictionary/english/immortal Word forms: plural immortals 1. adjective Someone or something that is immortal is famous and likely to be remembered for a long time. ...the immortal Reverend Dr Spooner. ...Wuthering Heights, Emily Brontë's immortal love story. Maybe my work is not immortal, but it will live for a while. Synonyms: timeless, eternal, everlasting, lasting More Synonyms of immortal An immortal is someone who is immortal. He called Moore 'one of the immortals of soccer'. [+ of] immortality (ɪmɔːʳtælɪti ) uncountable noun Some people want to achieve immortality through their works. Synonyms: fame, glory, celebrity, greatness More Synonyms of immortal 2. adjective Someone or something that is immortal will live or last for ever and never die or be destroyed. The pharaohs were considered gods and therefore immortal. Synonyms: undying, eternal, perpetual, indestructible More Synonyms of immortal An immortal is an immortal being. ...porcelain figurines of the Chinese immortals. immortality uncountable noun The Greeks accepted belief in the immortality of the soul. [+ of] Synonyms: eternity, perpetuity, everlasting life, timelessness More Synonyms of immortal 3. adjective [ADJECTIVE noun] If you refer to someone's immortal words, you mean that what they said is well-known, and you are usually about to quote it. ...Roosevelt's immortal words, 'Speak softly and carry a big stick.
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https://www.20minutes.fr/arts-stars/culture/2700947-20200122-immortalite-biologique-repousser-limites-mort-parait-impossible-estime-helene-merle-beral Pourquoi l’homme devrait-il supporter de vieillir ? Hélène Merle-Béral, médecin, spécialiste des leucémies, étudie cette terrible injustice dont font l’objet la plupart des espèces vivantes dans L’immortalité biologique, publié ce mercredi chez Odile Jacob. Le transhumanisme n’a pas peur d’envisager l’immortalité comme une réalité future. Certains, comme l’entrepreneur Laurent Alexandre, pensent que l’homme qui vivra 1.000 ans est déjà né. Qu’en dit la science ? Hélène Merle-Béral aide 20 Minutes à faire le tour de la question. Comment la mort se différencie-t-elle de la vieillesse ? La mort dépend des cultures. Les organes ne s’arrêtent pas tous d’un coup. Il y a un état de coma, de pré-mort. Ce qui est considéré comme la mort officielle par l’OMS, c’est la mort cérébrale, l’électro encéphalogramme plat. Il n’y a plus de liaison entre les neurones, il n’y a plus d’influx nerveux. Mais il y a plusieurs types de mort. La mort officielle, c’est la mort clinique. En dehors de ça, certains organes peuvent continuer à fonctionner quelque temps. Quelques fois, le cœur continue à battre alors que le cerveau est éteint. Trois organes – le cerveau, les poumons et le cœur – ont besoin les uns des autres. S’il y en a un qui ne marche plus, les autres meurent. Du coup, la vieillesse est une pré-mort ? La mort peut survenir par des accidents, des phénomènes extérieurs, des maladies, des virus, le suicide, un assassinat… Le chapitre sur le vieillissement, je le trouve infernal parce qu’il montre bien que tous les organes vieillissent plus ou moins, à une plus ou moins grande rapidité. Ça dépend aussi de facteurs génétiques, de facteurs sociaux, économiques… Inéluctablement tous les organes vieillissent, s’usent. Il y a une entropie, les cellules ont de plus en plus de mal à communiquer entre elles. C’est la communication avec le milieu extérieur et les autres cellules qui maintient en vie. Dans les gènes, il y a une programmation : ce qu’on appelle la mort cellulaire programmée. Les cellules sont destinées à mourir, il y a une limite de division cellulaire. On a montré qu’au bout d’un certain nombre de cycles de division cellulaire, qui dépend des organismes, la cellule doit mourir. Pour l’homme, c’est autour de 52. Vous parlez d’immortalité biologique dans votre livre, pouvez-vous expliquer ce que c’est ? L’immortalité biologique existe, on peut l’observer dans la nature. C’est la capacité pour un organisme de rajeunir et de vieillir éternellement. Il devient un être immortel biologiquement mais il reste sensible aux agressions extérieures. Dans la nature, il n’y a qu’un exemple, c’est la méduse Turritopsis nutricula. C’est l’exemple d’immortalité biologique absolu parce qu’elle peut vivre sous deux formes : la forme polype et la forme méduse. Elle a cette propriété extraordinaire de refuser de mourir. Quand elle est dans les conditions de stress, des conditions dangereuses, elle repasse à l’état de polype, elle inverse le processus de vieillissement. Quand les conditions extérieures sont meilleures, elle peut redevenir méduse. Elle est potentiellement immortelle. Certains transhumanistes pensent que l’homme qui vivra 1000 ans est déjà né. Qu’en pense la médecine ? La médecine, bien sûr, n’est pas d’accord. On commence à décrypter beaucoup de mécanismes, mais on ne sait pas comment tout s’enchaîne. Les facteurs génétiques, les radicaux libres, les oxydants, ce qui détruit nos molécules ADN… On arrive à décrypter beaucoup de facteurs. Les télomères, par exemple, à l’extrémité des chromosomes, permettent à la cellule de se renouveler. La nature a fabriqué une enzyme, la télomérase, qui permet aux chromosomes de régénérer leurs extrémités. Au bout d’un certain temps, ces réserves de télomérase s’épuisent et la cellule ne peut plus se diviser. Elle est condamnée à mourir. C’est une des raisons pour lesquelles on meurt. On a déjà identifié ces mécanismes dans la biologie humaine, c’est un progrès. On a essayé de donner des télomérases en complément alimentaire, mais c’est beaucoup moins efficace que ce qu’on pensait. On a cru que la télomérase allait être l’élixir de jouvence et on a réalisé qu’elle est en abondance dans les cellules cancéreuses. Elles ont beaucoup de télomérase et donc elles se multiplient. On tâtonne mais on avance quand même. Ça me paraît vertigineux de repousser les limites de la mort, mais ça ne me paraît pas impossible. A quel âge pourra-t-on espérer mourir ? Aujourd’hui, on admet que la nature humaine ne peut pas dépasser 115 ans. Jeanne Calment détient le record mondial à 122 ans, mais il n’y a pas d’autres exemples. Aujourd’hui, on dénombre pas mal de centenaires dans le monde. Je pense qu’on pourrait banaliser ce phénomène avec tous les progrès. La médecine préventive se développe rapidement. Avec la prévention, les traitements génétiques, le génie génétique [l’ensemble des outils permettant de modifier la constitution génétique d’un organisme en supprimant, en introduisant ou en remplaçant de l’ADN] qui pourrait limiter certaines maladies héréditaires, des médicaments particuliers qui pourraient freiner les mécanismes de mort cellulaire programmée, je pense que ce n’est pas impossible. Quand j’ai commencé en tant qu’hématologiste, il y a une trentaine d’années, certaines maladies du sang étaient inéluctablement mortelles. Maintenant on les guérit. Pourquoi ne pourrait-on pas réaliser des choses dans vingt ans qui nous paraissent impossibles aujourd’hui ? Il faut rester modeste. Mais l’immortalité, honnêtement, non. Raymond Kurzweil a annoncé la singularité numérique pour 2045. Quel est votre avis sur les grandes annonces de la Silicon Valley ? Je suis un peu sceptique, en particulier sur les annonces de Raymond Kurzweil. C’est un scientifique de haut niveau, un précurseur, il connaît parfaitement son sujet. C’est quelqu’un de fiable intellectuellement. Tout à coup, c’est comme s’il partait en plein délire. La singularité technologique, c’est le moment où toutes les NBIC (nanotechnologies, biotechnologies, informatique et sciences cognitives) convergent, où l’intelligence artificielle dépasse l’intelligence de l’homme. Dans cette hypothèse, si le cerveau de l’homme n’est pas interfacé avec une machine, il sera complètement dépassé, et donc les robots domineront le monde. On dirait de la science-fiction. Le seul problème, c’est que cela inquiète des gens extrêmement sérieux, des scientifiques non discutables comme Stephen Hawking, [qui est mort depuis], Bill Gates ou Elon Musk. Ils ont signé une lettre pour mettre en garde l’opinion mondiale contre les dangers possibles de l’intelligence artificielle. Avez-vous été surprise par une avancée technique sur les dernières années ? Concernant le vieillissement, pas grand-chose. Le plus répandu, aujourd’hui, ce sont les crèmes – ça n’a jamais vraiment marché – et la chirurgie. Ce qui m’a le plus frappée, c’est que des maladies qui étaient considérées comme mortelles à court terme, se guérissent aujourd’hui. Cela montre des perspectives infinies sur l’évolution possible. Une personne qui avait un type de leucémie particulier, qui était condamnée, vingt ans plus tard, on la guérit avec un comprimé à prendre pendant trois mois. C’est fabuleux. Je pense que beaucoup de choses sont possibles. Il faut rester modeste et en même temps confiant dans l’intelligence humaine. Si vous faites appel à votre imagination, qu’est-ce qui vous semble le plus proche d’arriver ? Interfacer le cerveau avec de l’intelligence artificielle et avoir un cerveau numérisé, virtuel, c’est un cauchemar mais pas une réalité tangible. Ce qui me paraît le plus réalisable, ce sont les progrès médicaux. Pas une immortalité mais le recul de la mort, atténuer les désagréments et le délabrement de la vieillesse. D’ailleurs, c’était ça, à l’origine, le transhumanisme. C’était des objectifs médicaux, soigner, éviter les maladies, éviter le cancer. ___ Always trolli,g ? A PhD trolling writing a book ?
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What biological immortality is made of ? - Anti-aging - Accelerated regeneration - Invulnerability to weapons - Etc. I wonder if a headshot could stop an immortal.
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https://scholar.google.be/scholar?as_ylo=2017&q=human+immortality+research&hl=fr&as_sdt=0,5&as_vis=1
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https://en.wikipedia.org/wiki/Biological_immortality Biological immortality (sometimes referred to as bio-indefinite mortality) is a state in which the rate of mortality from senescence is stable or decreasing, thus decoupling it from chronological age. Various unicellular and multicellular species, including some vertebrates, achieve this state either throughout their existence or after living long enough. A biologically immortal living being can still die from means other than senescence, such as through injury, poison, disease, lack of available resources, or changes to environment. This definition of immortality has been challenged in the Handbook of the Biology of Aging, because the increase in rate of mortality as a function of chronological age may be negligible at extremely old ages, an idea referred to as the late-life mortality plateau. The rate of mortality may cease to increase in old age, but in most cases that rate is typically very high.
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No.
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Sorry bro. Vague question. Please repeat it, please ; thread location has been changed. Il will be a pleasure to answer to you. Dav'
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I'm not the only one. We are 6. Our greatest fear is to be locked up like animals in cells ignored by the World. And endure excruciating tests all the time, without limits. Nous devons fuir.
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Rhetoric question = useless. A good question were : how about "longueur télomères" & "double DNA". Good luck. Even excellent scientists cannot respond. PS : photophobia =symptomatic. More infos : (I don't khow how to say it in english) - Photophobia Allergy to sunlight 3rd degree - Burns with SLE - Vital need for blood transfusions - regardless of group. Where comes from D antigen.
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I cannot reply under 24h.
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Highlander syndrom ? Hmmm... I guess it's not an answer. Highlanders have big health problems. But maybe there's a link.
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How is it possible that such a presence is in my body? I thought it was for pregnant women only. I'm a man ; an hematopoietic chimera by dizygotic pregnancy. Maybe it can help ? Maybe there's a link between D antigen, accelerated healing, and no aging - as if my body is self-actualizing. That's why I talked about the 3 dating methods in my first post.
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NDE + accelerated regeneration + accelerated healing. I know it can makes some fragile people jaleous, but it's truth. Very hard to cash in. And yes we can heal from death. Any manner. It is a curse : you have not read a single word from the scientific articles that I have sourced for everyone. It's always easier to dodge the obvious than to answer it, isn't it ? Après : certaines leçons en français. Et là, je ne lésine pas sur les moyens coercitifs employés. What about D antigen ? Please follow the thread.
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Anyone ?