BV63

https://news.yahoo.com/covid-vaccines-cant-keep-omicron-145138040.html COVID vaccines can't keep up with new Omicron subvariants New subvariants of the Omicron strain of the COVID-19 virus "appear to be even more immune-resistant than the original," Axios reported Wednesday. The original Omicron strain was known as BA.1, but that's old hat by now. All the cool kids are getting BA.4, or even BA.5. Unfortunately, while the virus has moved on, vaccine makers are stuck in the past. Per Axios, "[c]linical trials are underway to study tweaked versions of the Pfizer and Moderna vaccines" designed to tackle O.G. Omicron, but by the time they're ready — this fall at the earliest — it might be too late. You think i am here for fun you complete idiot?

No. Variants are already becoming resistant and vaxxed have less natural immunity. https://www.medrxiv.org/content/10.1101/2022.04.02.22273333v1.full

Pfizer forgot to write that the fake vaxx can wipe out humanity in case to many take the shots.

No because of immune imprinting the vaxxed get infected again and again. "Conclusion We report high incidence of omicron infections despite recent booster vaccination in triple vaccinated individuals. Vaccine-induced antibody titres seem to play a limited role in risk of omicron infection. High viral load and secretion of live virus for up to nine days may increase transmission in a triple vaccinated population." https://www.medrxiv.org/content/10.1101/2022.04.02.22273333v1.full

No. The virus is still there mutating in the vaxxed. That is the difference between a real vaxx and this one. So it´s pretty much guaranteed resistant and more dangerous variants become competitive. It´s the same principle as with antibiotics. Using to much can be dangerous if it does not wipe out the bacteria.

And a year later. "COVID reinfections set to spike in U.S. as new variants evade immunity"

But you seem to believe that scientists can not make misstakes.

All medical drugs must be good? Side effects are just a conspiracy theory?

Ok 🙂 Keep injecting and hope to win the race against billions of years of evolutionary power. Seems very risky.

Then prove why the risk that the virus will mutate to a more dangerous variant for the vaxxed is low. You simply have no idea. Why would such a variant not be possible and become competitive? If you can not explain why such a variant is not possible why should we inject the whole world with this vaxx when most people are naturally protected? Are you insane? Again: "The goal, they say, should be "to reduce infection of and transmission from vaccinated individuals," and to "reduce the possibility of variant selection in vaccinated individuals." "They write that some variants that have emerged over the past few months "show a reduced susceptibility to vaccine-acquired immunity, though none appears to escape entirely." But they caution that these variants emerged "before vaccination was widespread," and that "as vaccines become more widespread, the transmission advantage gained by a virus that can evade vaccine-acquired immunity will increase." https://edition.cnn.com/2021/08/01/health/uk-scientists-covid-variant-beat-vaccines-intl/index.html

Just want to help. Is it not obvious that this mass vaxx will lead to disaster? Like giving everyone on the planet antibiotics at the same time although 99% have a natural protection. Viruses mutate and the protection from the shots is very narrow. "The goal, they say, should be "to reduce infection of and transmission from vaccinated individuals," and to "reduce the possibility of variant selection in vaccinated individuals." https://edition.cnn.com/2021/08/01/health/uk-scientists-covid-variant-beat-vaccines-intl/index.html "The approved COVID-19 vaccines, on the other hand, all target a single protein — and two of them only a short stretch of that protein. If mutations change the shape of that protein, it could easily make our vaccines less effective. Studies of this question are still underway, but the initial evidence is worrying. At least some of our vaccines seem to be somewhat less effective against some coronavirus strains now in circulation. Focusing on a single protein contributed to the record-breaking pace of COVID-19 vaccine development. But it also produced narrowly focused vaccines that could falter in the face of viral variation." https://evolution.berkeley.edu/evo-news/viruses-variation-and-vaccines/

... It would not be the first time scientists find that drugs can be used for other problems than the drugs were approved for. I read a recent study that ADHD meds may help for Alzheimer to.

Ok a suggestion. Can you help finding out why ADHD meds will work for VAIDS? I assure you it is the truth. So you can help lots of people and perhaps also make lots of money. I read this but have no idea if that is why some ADHD meds will help for VAIDS. "Some adhd meds are methyl donors, boosting methylation in the body protects a person from many viruses because it tightens up the dna and slows replication of everything"

Goddess Kali have told me many times. Wrote that before. Chronic Covid would be like AIDS i suppose. Damage to T-cells i read.

Ok! As i wrote i am looking for studies to confirm what i already know. That VAIDS is real. Hard to convince others otherwise. That ADHD meds will save peoples lives. It´s just the truth but few will of course believe it without some sorts of scientific explanation.

Here is one. Perhaps there are others. https://www.medrxiv.org/content/10.1101/2022.04.18.22271936v1 Igor explain what it means. https://igorchudov.substack.com/p/moderna-knew-vaccinated-people-will?s=r "This study looked at two sides of the Moderna Phase 3 vaccine trial: the vaccinated group and the control group. They looked at unvaccinated people having Covid, versus vaccinated people having so called “break-through Covid infections”. Skipping some details, our natural, unvaccinated immunity learns to recognize the “spikes” (S-protein), the “nucleocapsid” (N-Protein) and other pieces of the virus, and develops antibodies and immune memory reacting to all of those. This multifaceted memory also provides broader protection against “variants”. In contrast, vaccination with any existing Covid vaccine, floods our cells with only S-protein (the “spike protein”) from a virus that only existed around January 2020. The difference between the vaccinated and the unvaccinated is FIVE TIMES, which is huge. The unvaccinated are five times more likely than the vaccinated to develop broad immunity including N antibodies. for those vaccinated persons whose breakthrough infection occurred after the second dose, (illness detected on Day 29), their ability to develop N antibodies was 13 TIMES worse than that of the unvaccinated. This inability to obtain broader natural immunity is the reason for endless covids: a covid infection in the vaccinated does not result in lasting immunity and acts similarly to an almost-worthless booster shot. A “breakthrough infection” adds a large number of temporary S-antibodies to the obsolete Wuhan virus. Whereas, the unvaccinated obtain numerous antibodies to all sorts of facets (epitopes) of the virus that infected them."

Ok..CDC is enough? https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html How mRNA Vaccines Work To trigger an immune response, many vaccines put a weakened or inactivated germ into our bodies. Not mRNA vaccines. Instead, mRNA vaccines use mRNA created in a laboratory to teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. That immune response, which produces antibodies, is what protects us from getting infected if the real virus enters our bodies. First, COVID-19 mRNA vaccines are given in the upper arm muscle. The mRNA will enter the muscle cells and instruct the cells’ machinery to produce a harmless piece of what is called the spike protein. The spike protein is found on the surface of the virus that causes COVID-19. After the protein piece is made, our cells break down the mRNA and remove it. Next, our cells display the spike protein piece on their surface. Our immune system recognizes that the protein doesn’t belong there. This triggers our immune system to produce antibodies and activate other immune cells to fight off what it thinks is an infection.

The vaxx induced abs recognize only the S-protein no?

Natural infection gives you a broader protection. With the shot it seems one get more and more non neutralizing abs. Dangerous variants have no advantage because people isolate etc. But now the distance is closer. Guess that is what Bossche mean when he mention this equilibrium.

Basically if i understand Bossche the problem is the narrow protection from the shot + immune imprinting. So when the virus is resistant infections in the vaxxed lead to a boost of non neutralizing abs. It becomes a vicious circle. Those abs prevent severe disease but eventually the virus will likely mutate to variants that will overcome that immune pressure. More dangerous variants. Guess they can spread easier because the distance between vaxxed is shorter.

That is Bossches major concern and he refer to studies. Suppose this is what you mean. That non sterilizing abs prevent severe disease. Because he believe it is only a matter of time until the virus overcome this immune pressure as well. Called trans-infection if i understood what he meant. This is Greek to me but perhaps you understand. From Bossches paper. "Natural selection of new, O-glycosylated variants, which I have predicted to rapidly emerge (https://www.voiceforscienceandsolidarity.org/scientific-blog/predictions-gvb-on-evolution-c-19-pandemic),would allow to overcome binding of both, potentially infection-inhibiting (i.e., neutralizing) Abs directed at theimmuno dominant receptor-binding domain (RBD) and potentially ‘trans infection’-inhibiting (note 2) (i.e., virulence-mitigating) Abs directed at the conserved antigenic site within the N-terminal domain of S protein (S-NTD). Consequently,O-glycosylation of the S-RBD would overcome population-level immune pressure that results from boosting of vaccine-primed Abs directed at conserved NTD-specific epitopes that cross-protect against severe disease. This is because NTD-associated ‘trans infection’-inhibiting (i.e., virulence mitigating) epitopes will be shielded against their corresponding Abs by the O-glycosites inserted at the predicted O-glycosylation sites of the new variants (New covariants). At the same time, these O-glycosites would also shield RBD-associated infection-inhibiting (i.e., neutralizing) epitopes against their corresponding Abs. Natural selection of the O-glycosylated Newco variants would, therefore, enable SC-2 to effectively counter the growing virus-neutralizing and virulence-mitigating capacity of a highly vaccine-experienced population that is exposed to Omicron, and thereby relieve the pressure on the viral life cycle. The more Omicron expands in prevalence and the more frequently vaccinees get re-exposed and fall victim to breakthrough infections, the higher the prevalence of both elevated virulence-mitigating anti-S Abs will become. The higher this prevalence and the higher the anti-S Ab titers, the higher the site occupancy of the predicted O-glycosylation sites will need to be for Newco variants to resist the trans infection-inhibiting immune response of Omicron-infected vaccinees. This is because more densely O-glycosylated variants will more effectively prevent mitigation of viral virulence. Given the population-level immune pressure caused by the exposure of highly vaccinated populations to the highly infectious Omicron, Newco variants will primarily rely on glycosite instead of amino acid mutations in their RBD to gain the required fitness advantage in a landscape of increasing population-level immune pressure on S-NTD. This already explains why the upcoming Newco variants are likely to evolve to a super variant that is not only highly infectious but also highly virulent and fully resistant to C-19 vaccines, including those that have been adapted to the spike protein of the circulating variant. This is why the authors of this paper are desperately wrong in thinking that tailoring the vaccines to the polypeptide sequence of S on the dominantly circulating variant would have a beneficial effect on the outcome of the mass vaccination program. On the contrary, usage of so-called ‘updated’ vaccines to continue this program will only aggravate the outcome due to further boosting of anti-NTD Ab titers. Conclusion:In the absence of large scale antiviral prophylaxis, the vicious circle of steadily increasing immune pressure causing steadily rising infection rates will ultimately drive highly vaccinated populations to promote the expansion of a super variant that will likely be featured by full resistance to potentially neutralizing epitopes (due to lack of immunogenicity of these epitopes) combined with a high propensity to cause Ab-dependent enhancement of infection (ADEI; facilitated by the infection-enhancing Abs) and a high propensity for causing ADEI-mediated Ab-dependent enhancement of disease (ADED).This is how the evolutionary dynamics of the virus will unfold and how the end station of this misguided mass vaccination program will look." ‍

All you wrote then was: "Who says the Covid vaccines damage the immune system? I’ve never read anything to suggest that. Nothing you have posted so far seems to support such a suggestion. " Try again and explain why we should not fear that the world now is a giant gain of function lab instead. This one seems obvious to me as i wrote. If those other ideas from Bossche (Backed up by studies he says) about immune imprinting and non sterlizing abs are true i was hoping people in here could answer. "Harvard Epidemiologist Warns People About “Immune Escape” After New COVID-19 Vaccines. In response to the many questions that he got regarding all of this, Harvard epidemiologist, immunologist, and physician Michael Mina went to Twitter to elaborate on why there’s also a great need for a contingency plan despite vaccines already reaching the public."

"COVID vaccines can't keep up with new Omicron subvariants New subvariants of the Omicron strain of the COVID-19 virus "appear to be even more immune-resistant than the original," Axios reported Wednesday. The original Omicron strain was known as BA.1, but that's old hat by now. All the cool kids are getting BA.4, or even BA.5. Unfortunately, while the virus has moved on, vaccine makers are stuck in the past." https://news.yahoo.com/covid-vaccines-cant-keep-omicron-145138040.html

I suggest you look at his CV. You obviously have no idea what you are posting and no thoughts about the science. Why are you not thinking for yourself? Instead you come here to pretend to understand but just post BS. "Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein The deployment of vaccines against SARS-CoV-2 brings the question of mutational escape from antibody prophylaxis to the forefront. Rapid evolutionary evasion of neutralizing antibodies (nAbs) poses a number of threats to biomedical interventions aimed at bringing the virus under control, namely the risk of reduced vaccinal efficacy over time as resistant variants continue to emerge (which may or may not be rectifiable with annual vaccine updates), the risk of waning effectiveness of natural immunity as a result of evasion of common nAbs, and the risk of antibody-dependent enhancement (ADE)." https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0250780

I guess you have heard of him. Basically as i understand he says it was insanity to mass inject people with a "leaky" vaxx during a pandemic. Because we left the virus to mutate so that resistant variants will have an advantage and become dominant. He also expects more dangerous variants. As far as i understand he mean non neutralizing antibodies take over when the virus is resistant to neutralizing abs. The non neutralizing abs protect against severe disease but eventually there may be variants that overcome this immune pressure. Usually dangerous variants can´t spread well but what about now when so many got the shots? So he recommends governments implement large antiviral drug campaigns in heavily vaxxed countries. What do you think of his thoughts? The first parts about the danger of mass vaxxing this way seems obvious to me. An interview with Bossche from April. https://www.voiceforscienceandsolidarity.org/videos-and-interviews/deadlier-variants-dr-geert-vanden-bossche-on-what-to-expect-in-the-near-future-and-why