If you look at the animal kingdom, the weak members play a vital role in keeping the community alive. They get preyed upon first, distracting the predators, and allowing the strong to run the hell away. They participate in recipricol altruism, and they increase the members of the species by reproducing and allowing for more genetic recombination.
A disease like sickle cell anemia doesn't seem so great, but neither does malaria. If we didn't have the reccessive genes that cause sicke cell (and makes people sick and "weak"), the african population could have been seriously been decimated by malaria.
The problem with eugenics, with playing God, is that you cannot predict the traits which may be valuable to our species in the future. What if you eradicate genes that could have future benefits, but seem "weak" in the present. Really we should be focusing on trying to better understand our genetic diversity before we try to take nature's job into our own hands.