Obscurity

Something I found in relation to the subject: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15288677&query_hl=1 So does that mean that no negative feedback would occur? However note that those people who were on HRT were also on anti androgens. So what about having only estrogen?

I'm rather curious, I know that people who undergo sex changes would have to go for HRT(Hormonal replacement therapy) but I have a few questions about it: How would it work since the additional hormones would have to override the natural body system? I mean, for lets say a person changing sex from male to female, s/he would have to take estrogens/anti androgens but the thing I do not know is will the body produce a negative feedback and produce more testosterone until the levels of testosterone and estrogen equal out such that a plateau is reached? (I know that people taking anabolic steroids would produce a similar effect with the hormone cortisol and would result in Cusher's syndrome. This as a result would limit the effect of the anabolic steroid since an increased amount of cortisol in the bloodstream would compete for the receptors on the cell surface and so a greater amount of anabolic steroid would have to be administered to have an effect) and would anti-androgens block the release of more testosterone into the bloodstream?