The work of Urey & Miller at the University of Chicago showed that when an electrical discharge (representing lightning) was passed through a gas chamber containing methane, ammonia and hydrogen (representing the early atmosphere) in a controlled experiment complex amino acids were produced after only one week. Follow up experiments using UV radiation instead of electricity produced nucleic acids - the precursors of RNA and DNA.
Also the microspheres is still just a theory, but they are only made from lipids (C,H & O) and they have also been found to form under controlled experimental conditions.
The part that's still causes the most confusion is how the two processes actually came together, but you have to remember all this is happening over evolutionary time frames, i.e. millions of years.