I preferably want a practical way to do this not a way that would work on paper.
I tried to get a NH2 group on benzene first:
~Benzene + HNO3/H2SO4 ---> Benzene-NO2
~convert that to an amine by hydrogenation H2/Pd
But then I couldnt use a Friedel Craft Acylation to add an aldehyde to the ring because the aryl amine will react with the acyl chloride and make the reaction extremely slow:
Benzene-NH2 + CHOCl ---> Benzene-NHCHO
but on the other hand, that could be the protecting group to the amine. Is there any other way to add a carboxylic acid onto the benzene ring after that step?
<BR class=last-child>any thought is highly appreciated. Thank you.
