konstantin

does somobody works with chlamidia pneumoniae? please respond!!!!

if somebody works with TLR family, please contact with me. e-mail: konstantintsoy@yahoo.com

thank's a lot

actually I did not get, what do you need? you ask about what methods you can use to detect apoptosis or necrosis hapen in your cells...if apoptosis you want to know and prove through what pathway? is it like that? I am investigating apoptosis in keratinocytes....induced by UVB...

you mean because of physical inability to interact in nature.....??? macrophages in blood and e-coli in gut....???

one model to induce sepsis is to treat macrophages with LPS from E-coli. but we have many E-coli in our gut, why macrophages do not atack that E-coli and their LPS? thanks for any reply

mmmmmm yeah sorry, I misunderstood you. you are absolutely right...

Why?!!! it has no any usefulness, it kills bacteria which disrupts balance in our body. in addition cytokines attract lymphocytes and they memorize specific antigen.....at this point we have link between innate and adaptive immunity.

about involvement of COX-2 in cancer development. that is link may-be will be useful for you http://www.nature.com/jid/journal/v126/n1/abs/5700014a.html;jsessionid=23B93A64EAC5B80D6194A7E0099EC13E and you can easily find a lot of articles related to cancer, COX-2 and prostaglandins in pubmed. as to infection, bacteria entered into our body and provoke inflammation, if we will not control this inflammatory process it can lead to overexpression of inflammatory mediators such as prostaglandins, and in conclusion can get septick shock "death". therefore, scientists focus on the inhibition of such key point enzymes as COX-2, and of course other mediators of inflammation as iNOS or cytokines TNF-a, IL-1b and so on. Inflammation is necessary process in host defense but overexpression can damage host body itself....

hello everyone. I have a simple question for pundits in immunology . I know that IRF-3 is activated through its phosphorylation and subsequent translocation from cytosol into nucleus. but it is vague for me how IRF-1 is activated. please explain or give some link where I can find useful information... thanks in advance

hello everyone. my problem is that with the help of what methods, experiments, I can detect the expression, activation of TLR-4 and other downstream proteins such as IRAK1, IRAK4, TRAF6, RIP1, and so on. thanks in advance.