I am taking a general biochemistry class at SJSU and I really need a tutor to help me with homework and studying for exams. I live in San Jose and I need someone located in the south bay area.
This is an example of the homework problems that I need help with:
The X-ray structure of Hb Rainier (a Y145Cβ mutant of HbA) indicates that the
mutant Cys residue forms a disulfide bond with another Cys residue in the same
subunit. This alters the position of the β subunit’s C-terminal and prevents its
participation in a key salt bridge that normally stabilizes the T-state of the Hb
molecule. Explain how the following parameters would be altered in the mutant Hb
with respect to those found associated with HbA.
a) Oxygen affinity
b) The magnitude of the Bohr effect
c) The Hill constant
d) The observed 2,3-BPG affinity
