makgoz

Thanks Revenged and Inow As you said we might concentrate on gestational diabetes, Insulin resistance, not the level of insulin and came up wtih some possible answers, Increased ketone bodies (and ketoacidosis) (or increased Glokagon due to hunger) may i- change the levels of some hormones which may cause Insulin resistance ii- somehow directly affect Insulin receptors iii- somehow interfere with the Glucose transporters Which one, I don’t know If the case might be related with gestational diabetes only, then we might have to look at other hormones ???? I have read 10 biochemistry books and searched pubmed and internet , but there is no clue

I have taken an oral exam in TURKEY to qualify as an Assoc. Prof. The following question was asked and I did not know the answer, I failed the exam. They will ask it again. Pregnant women carries table sugar (sucrose) and when she gets hungry, she takes sugar, thus ketone bodies production decreases. If she is hungry for a long time, ketone body production will increase and that will cause Diabetes. In other words, Ketone bodies production causes Diabetes, what is the mechanism behind this phenomenon? As I know, Diabetes patients have higher ketone bodies production, since they can not use Glucose, body breaks down fats and free acids to Acetyl CoA which forms ketone bodies in the liver. I appreciate all your comments. Thanks a lot