magic-qwerty

Hi Pioneer Thanks again for your intersting post, Theres so much complexity going on at the molecular level, everything seems so elegantly preprogrammed, its quite fascinating by the idea of how proteins and other components in the cell talk to each other.. and know what to do...like one massive piece of clockwork, with the proteins as the gears... I guess this language cant properly be deciphered untill every protein structure in the cell is known ... Thanks Qwerty

Hi Pioneer Thanks for your post, Lots there to think about,,, so fascinating to picture this "tug of war" going on in side our bodys by all these forces acting on the protein, its remarkable with all the variables involved that proteins correclty form there shape. its like as if the dna knows what sequence to use so that the forces acting on it will make that shape needed. if the protein looses the tug of war and makes a wrong shape do we get ill..and die...?! i guess the computer scientists / statisticians are working with the biophysicists to look for clues and patterns in existing known protein structures , and see how that data could help provide a better energy model for protein structures Thanks Qwerty

ok, had no idea the current "state of the art" in this area was so lame.. was reading up on things that try to simulate energys of protein shapes.., all this molecular mechanics and dymanics is way above my head but it seems a lot of people need to go back to the drawing board

Didnt they use the most powerful computer ever built to do something like this,, and it was still to slow .. just a thought though if you do have a some kind of approximate simulation, surely you can test how it works with a known structure , just input in a amino acid sequence of it and see how closely it resembles the one in real life...? Im personally in to looking at sequences and what clues they might have with regards to the structures that are under simlar classsifications ( CATH, or SCOP etc)

Thanks again Paralith, Theres something so cool about the fact of every thing being "in the sequence",,, i guess its what appeals to people from a non biochemistry background.. like all these hidden secrets in the sequence ... Mr Skeptic, thanks for adding, yes i used to think that as well..but as Paralith mentioned that a different sequence causes a different shape to form when they react with chaperones,,, so its i think just some thing additional to the "system" that makes the overall proteins... with the input being the sequence Thanks Again qwerty

Hi Thanks a lot for clearing this up for me, ive defintenly got it now!...lol wish the text books were as clear , im not from a molecular biology background, but fascinated by proteins,,, so these amino acids form the tertriay structure .or proteins, and proteins can join with other proteins to form a quaterniary structure if its possible.. it so fascinating , i mean these proteins joining togther,,,like some biig jigsaw puzzle...to form this quaterniry thing.. Just one thing im curious (sorry to keep posting) . if a amino acid sequence has all the info needed to make that protein and hence we get that 3d structure of it, does the quaterinly structure have anthing similar... i mean if we have a protein do we know just from its shape or architecture that its likes to be "sociallable" (join with others as a quaterniry) or prefer to be on its own,, Thanks again M Qwerty

Hi There Paralith Thanks for replying, so its like one single amino acid sequence e.g Heemoglobin that forms everything i was kind of getting confused, i thought it was like different proteins joining togther to form a large unit thanks again m-qwerty

Hi there Science Forum ! I was just reading about the levels of protein structure, but was a bit confused what was meant by quaternity structure of a protein, in that if you have a protein sequence i understand that it will form a tertiary structure from that amino acid sequence for sure, but will that same amino acid sequence also make it form a quternity structure (if that protein structure is of that kind ) aswell. I mean take Heamoglobin ive read it has a quaternity structure , did that structure form by the amino acid sequence ? or does every protein form a tertiary structure only and then some how they join with other proteins to form a quaternity structure.? Thanks for reading, (im a bit if an amateur to all of this, !) Magic - qwerty