Hi,I just have a doubt that has been puzzling me from Years.So here is it in the best way i can explain
"A Non Virulent Bacteria When Genetically tailored to Produce Surface Molecules on its surface(My main thought is about producing CD4 molecule called CCR5 on its surface)When introduced inside a host of A Viral disease(HIV is my main concern),Thing is an obligate Virus is blind,It strictly detects cells by its Surface molecules & attaches to one to whom it has affinity.So HIV has to make a Choice,either CD4+T lymphocytes or The newly Introduced Altered Bacteria which has the selected CD4 on its surface ie CCR5 molecule(Considering a 50% chance to bind either of them).If half of virus population chooses Bacterial CD4 instead of CD4+T Cells,Their Genetic material is Trapped inside bacterium.considering their Obligate Nature,Which means their genes wont work in the Hostile Bacterial environment.Then Phasic removal of Bacteria i dont know whether dialysis can work or not but to my knowledge even tobacco mosaic virus can be filtered,Which means if the virus trapped inside bacteria r removed it means were achieving progressive reduction in viral load which like tuberculosis treatment takes time but does have a possibility to remove any obligate virus"
I am new to the forums so apologies for any mistakes.
as a medical student i know that Hep-B vaccine is cultured using its gene in Yeast cells by R-DNA.
I also believe that if selected bacteria has one type of antigen only & if that is replaced by human molecule,It escapes human immunity which has its own applications......
Non virulence is chosen to not harm human body
I also want to use "Incomplete Antibodies" against CD4 T cells before bacterial introduction to mask their Antigens so HIV wont attack remaining CD4 t cells besides Improving its affinity towards artificial Bacterial CD4 but its a Costly process
Whole Process is costly,But Calmette & Guerrin worked 13 years on BCG vaccine working on 239 strains so i believe this has a chance too.Its role can be used on many obligate viruses.Thank u