There are several non-PCR based whole genome amplification methods typically referred to as "Next Generation Sequencing" (NGS), as opposed to Sanger sequencing. Some of the most common NGS systems are 454 pyrosequencing, Illumina sequencing, and more recently the Ion Torrent sequencing technology. These methods take advantages of generating large numbers of short reads around 100-200 base pairs in length, and then using high throughput computing to link together these short fragments into a single "consensus" genome.
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