Hi,
It is most likely that whatever protocol you choose, you’ll need to tweak it for your laboratory set-up. I would recommend (as a starting place) the method in this paper: http://www.ncbi.nlm.nih.gov/pubmed/22844078 because it is used by a lot of the comet assay leading labs.
In addition, check out www.scorecomets.com – there are web pages about ‘getting started’ with comet assay and ‘troubleshooting guide’ which might be helpful to you.
Also, the kits by Trevigen might be a good place to start.
Best wishes!
