cbrons

A high degree of autosomal recessive disorders cropping up in the generation of the proband suggests cosanguinity. But what do you mean by modes of inheritance for these two diseases? It seems like you already know?

Nope, definitely skeletal muscle. Pretty big one too... intimately involved in respiration (inspiration to be exact). Innervated by the phrenic nerve, which arises from spinal nerves C3, C4, and C5 (also innervates the parietal paricardium (covering of the heart) and the pleura on the mediastinal side (side of the pleural cavity of the lungs facing the compartment of the thorax where the heart is situated). Incidentally chronic and severe hiccups can be treated surgically by crushing or sectioning this very same nerve).

Neural stem cells were not thought to exist in the adult, but we know better now. A small fraction (less than 0.5%) of ventricular ependymal cells (i.e. astrocytes) remain as neural stem cells (form neuroblasts that give rise to new neurons even in the adult). They are found in the hippocampus and olfactory cortex (in fact olfactory mucosa generates new olfactory neurons throughout life).