I've been looking into the chemistry of known treatments for scarred tissue. I'm particularly interested in Alpha Hydroxy Acids (Glycolic Acid), Beta Hydroxy Acids, Hyaluronic Acid, Retinol, any and all vitamins and Collagen. This is a diverse list and yet they are the main focus, as to my understanding, of substances used to treat scarred tissue. I'm looking into the mechanism which guide the use of these substances in treatment. For example, Glycolic Acid is used as both a general exfoliant and also a deep tissue skin peel. It is known to have the properties of softening skin and also reducing wrinkles. The means by which this is accomplished is through the breaking of lipid bonds and skin cells. This would seem to be a good means of reworking scar tissue and yet it is generally accepted as being not. Why is this? Is it because scar tissue has a higher concentration of TIII-Collagen and therefore a lower concentration of lipids? It is also to my understanding that a combination of AHAs, BHAs and Retinol seems to prove effective and yet a tolerance to a combination thereof will quickly develop. Why is this?
I know this is a very general topic of discussion but I hope to have some good general responses with regards to the chemical mechanisms.
Thx!