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It does not seem trivial to dissociate the issue based on OPs description (heroin laced with fentanyl). Also, considering that addicts pick and choose between different opioids depending on availability it may be insufficient to only one or the other aspect. I.e. addicts that got hook up on opioids may seek morphine or heroin to satisfy their addiction, if they cannot get oxycodone, for example. And this is what data suggests: ~2010 oxycodone use started declining, while heroin abuse started to increase. And more recent data suggest now a strong increase in fentanyl. As an additional issue, prescription drugs can and have been distributed outside of legal distribution routes, as especially for fentanyl the synthesis is not prohibitively complex. That is not to say that there are no means to reduce abuse using such means, as some pharmacies have started using an exchange system for fentanyl patches. However, focusing on only one part of the equation is unlikely to be sufficient to put a dent into the problem. It also makes sense to talk to social workers, addiction centres and researchers in that area, assuming that they are not already part of the discussion.

In that context a recent study is interesting: Barnett et al. 2017 New England Journal of Medicine. In that paper the authors found a link between addiction and high-intensity pain opioid prescribers (i.e. MDs that prescribe painkillers more frequently).

Organs are cooled, not frozen. Also you should check your computer for malware.

I think it is a massive oversimplification of widely different and complex issues.

I read about it a while ago and according to a Canadian report (Canada has seen one of the biggest increase in abuse) it could be linked to the decline of oxycodone, due to a change in formulation, which made oxycodone less usable for drug users. Together with the fact that fentanyl is relatively cheap to produce, there was surge in the illegitimate production and sales. It is probably relevant to note is that heroin has not gone away either, and currently oxycodone and heroin are still leading causes of overdoses. Fentanyl is mostly a worry as the deaths increased rapidly, again, most likely as it starts replacing oxycodone and many people get the dosages wrong. It is probably also relevant to add stimulants such as cocaine and methamphetamine to the mix. While stimulants account to maybe only ~20% of deaths their use is currently on an uptick. While we are in politic I would like to add that law enforcement and politicians have often viewed drug abuse as a gang problem or a minority problem (including the current president). As such it was often treated as a moral problem with all the issues and abuse that imatfaal brought up. However, it is clear that it is, and to some degree always has been a population-wide problem and has to be treated more like a health issue than a merely a criminal one. Ultimately, addicts are victims of their addiction and punishing them does nothing to change that. Potential because of the focus on specific groups, the constant increase of drug abuse among white people (check the SAMHSA survey, for example) has not sufficiently been recognized and targeted. And that is despite the fact that there are at least five times the amount of white drug users than blacks. Potentially, as it came with a moral burden health care responses were anything but adequate to address this situation while at the same time certain avenues of drug trade, such as prescription drugs, were not effectively shut down or reduced. So overall mistargeted law enforcement (no doubt supported by rhetoric of tough on crime politicians) together with inadequate health care at least contributed to the overall problem.

I agree, discussing the sources of addictions is important. Unfortunately it is easy to become addicted and there should be more awareness regarding the potential dangers. Somewhat related to that, it is interesting that certain minorities (African Americans and Hispanics, I believe) were less affected by the recent opiate wave and it has been speculated that it is because they get less pain med prescriptions. It is a bit ironic that the assumption of higher addiction rates prevented addiction in this demographic, whereas white folks suffered more. But it also means that a more controlled prescription and use of alternate ways of pain control could, at least in part, reduce the incidence. Another aspect of recent high fatality rate has been attributed to fentanyl, which is highly potent with higher toxicity leading to increased overdoses.

The whole area of genetics for starters. Also it is crucial to view his work in the context of the views held by his contemporaries. Much of his arguments is to challenge the view of a strict distinction between races, which is the more prevalent assumption at that time. In fact, many of the assumptions people had regarding races are more what one would later to attribute to species-level distinctions. Take a look at that part from the same chapter you quoted from Descent of man: He brings forth a stronger challenge on what was believed regarding interfertility of races: The next quote highlights how he and his contemporaries view, or struggle with the concept of fertility and species: Ultimately his argument is less about the need for the distinction of humans into races, but he uses it as a counterpoint to classify humans as species. Note that some contemporaries authors who did not view humans as distinct species could still held a view of distinct races that originated independent of each other. I think ultimately the issue is interpreting his writings from a modern viewpoint, whereas Darwin addressed and challenged contemporary beliefs. At that time it was assumed that humans had distinct species or races and Darwin argued that all were derived from the same stock. Modern population genetics not only verified that, but also highlights the degree of genetic flow between populations. Indeed the only subspecies that can be clearly isolated (potentially) will be highly isolated groups.

So yeah, what a scandal.

IIRC Darwin did not provide a rigorous definition. Mostly, he used it loosely to refer to any variety within a species. Also note that the Darwin also somewhat changed how he viewed species from his earlier to his later writings.

Has she been appointed? Well, at the very least she should have no problem with the temperature in winter.

As a matter of fact, "stages" is not really a good way to look at it.

That is not required for education, though, is it? I mean, instead of growth, they just need to decimate the competition, i.e. public schools. If the latter gets defunded they will look much better in comparison, if only for having computers and functioning toilets. The content becomes secondary at that point. Edit: Reason being that everyone has to attend school.

If there is no obvious reason to suspect an effect, why would anyone research it? There are a larege number of studies on caffeine intake and health issues but I have not seen anything affecting melanine production so far.

Don't remind me of that. I mean, what could possible go wrong with an entire for-profit education system with no accountability. Just look at the shining beacon of scholarly success that is the Trump University.

indeed.

In a recent poll people were asked: "Do you agree or disagree with the following statement: ‘the Bowling Green massacre shows why we need Donald Trump’s executive order on immigration?" 23% agreed, 57% disagreed, 20% not sure. Among Trump voters: 51% agree. 23% disagree, 25% not sure Clinton: 2% agree, 90% disagree, 8% not sure Johnson: 6% agree, 55% disagree, 40% not sure Stein: 3% agree, 50% disagree, 47% not sure Party: Democrat: A:7% D:83% N:10% Republican: A:46% D:25% N:29% Independent: A: 21% D: 56% N:23% It is troubling that a made-up event can cause so much uncertainty... Edit: wrong number.

Take a detailed look at which steps ATP appears in the reaction. Look at all steps starting from glucose.

Test:

One clearly can. He declared bankruptcy about four times, I believe. Also he somehow used the losses of his business to not pay taxes from future income. I am not certain how that makes sense, though.

Silk is also great. It is ... like silk. But maybe we should address the elephant in the room. Clothing is entirely unnatural and hence cannot be good.

Just as a completely different side note, but make sure that you have a control assay in place. Pull-downs can be notoriously unspecific. Especially high-abundance proteins, such as ribosomes tend to get co-purified very frequently.

To be honest, I don't get that. They could as easily stick to the two actual attacks and just ignore the fact that the travel ban would have made no difference. Just adding a made-up story does not (in mind) strengthen the argument at all. Edit: as it turns out it appears to be incompetence (or claimed as such). Spicer "clearly meant Orlando."

It is almost as if the administration is operating in an alternative world1 and are trying to merge it with the real world just by willpower. Considering what an hellscape the other world is, I'd rather not have them succeed. What does worry me is if their policy is based on the events of the other world. (1 You know, the one where there is American Carnage TM with ever increasing crime (black as well as various other darker hues), murder (ditto), terrorism (brown), job stealers (yellow I guess? but not orange. Orange is good) as well as a very successful Trump empire that never made debts as the released tax returns show).

Source I have absolutely no idea whether that is strategy or incompetence.

Everyone says so, believe me.