Locally and all up and down the east coast there is an influx of coyotes, they are killing pets and domestic animals, they were reintroduced to help keep down the deer population but pets are easier to catch... in a few places cougars are causing problems, out west they have killed several people in recent years, and bears are at an all time high and black bears are more likely to kill you than grizzlies...
Their have been some interesting consequences of the genetic bottle neck deer went through about 50 years ago in my old tromping ground, resulting in lots of albino, lecucistic, other weird colored deer.