cpazchem

Hey, i know its prob too late to be helpful. But, could someone read over my synthesis so i have an idea whether i am on the right track myself... I am not new to organic chemistry, but im only started second year uni (tho i am a few steps ahead of the bulk of the year), anyway, so if i dont know i particular way to do a reaction i will just discribe my thoughts if someone is ever able to elaborate on them. Anyway, so, looking at the product (second picture) i can see two 3-carbon chains, essentially a propyl substituant, and "propane chain"... i know its a hexane chain, but breaking it into the 3 carbon blocks... So, the propyl chain can be added using H3CCH2CH2Li (can be made from propene- bromination-etc) or being only 3 carbons, may be allowed straight up... Now, it will attack at a carbonyl group and make an alcohol, so thats that taken care of provided we make 1,2-dibromopropanal. So, to make 1,2-dibromopropanal, i was invisioning starting with 1propenol, oxidising with PCC (wont oxidise the double bond, and stops at aldehyde) to 1propenal- then reaction with Br2 to give 1,2-dibromopropanal. -----edit----- If Br2 would oxidise the aldehyde, then protection using Tosyl Alcohol (TsOH) and ethylene glycol in benzene. ----end edit---- You can then alkylate this at the carbonyl using the n-propyl lithium, followed by acid work up. Idk, but that seemed the simplest way? though i understand there would be many ways, but are there any major flaws in mine?

Thanx jerryshizzle123 for clarifying that for me. um dede22, the equation balances, but that doesn't mean it will work. a good example is that of the solvay process. CaCO3 + 2NaCl → Na2CO3 + CaCl2. The reaction has no go power, so to speak, so it is achieved in a 5 step process. The reaction NaHSO4 + Ca(NO3)2→ CaSO4 + HNO3 + NaNO3 is probably the same, although im not entirely certain.

I use Cl2 as my main precursor chemical (usually for making chlorates, gaseous HCl streams and stuff). As such i have a very effiecient and CHEAP way of making it. You will need 1) Adequate ventilation (outside is a must, unless you have a very good fume cupboard) 2) Calcium Hypochlorite pellets or granuals. (i get 70% in "pool chlorine" products, notably "pool shock treatments") 3) 37% Hydrochloric acid (this is the best acid to use because it is cheap) Ok so simply mix the 2 (eventually you will pick up on what amounts you need according to your applications). Most of the Cl2 gas will be liberated within the first 10 secs, in a reaction resembling that of the famous Bicarb/vinegar reaction [with a familiar green tinge of coarse ]. Ca(ClO)2 + 4HCl --> CaCl2 + 2H2O + 2Cl2 NOTE: Cl2 is a corrosive toxic gas... etc etc, im sure you have read the MSDS... also HCl is corrosive and will fume in moist air (note, although i have breathed these fumes at low concentration with no adverse respiratory effects, my teeth are now happy that i avoid it.) and of coarse Ca(ClO)2 is toxic and corrosive and OXIDISING!! oh, and bleaching, don't wear your good black pants... trust me on that one!

I got one, it fair easy! And you can try it without Sulfuric Acid, i don't know how effective it will be without it tho, maybe something to try. Ok, so main thing you need is Copper Oxychloride [CuO.CuCl2] (50-100%, the purer the better - can get as a pale blue/green pestiside dust from hardware, nursery, etc). Next dissolve 2 spoons or so into HOT WATER. Mix it around a bit. Now I add a dash or so of 90% sulfuric acid* (because the water is hot it can bubble and splatter, but I haven't had any massive issues with it). Then i leave it for a couple of days, this leaves it time so the water can evaporate and the CuSO4.5H2O recrystallises as large blue "rocks" so to speak**. They can then be washed and dissolved into de-ionised water or whatever. A powdery green/yellow precipitate will be left behind with the left-over solution, im not sure what it is, but can be discarded into bin once filtered off. *If you can't get H2SO4, you could possibly use NaHSO4, the only problem is that maybe Cu(HSO4)2 could form?? or Na+ ions will contaminate your crystals? I havent tried it. **If you try to force precipitation (by adding alchohol) then the tiny crystals formed will become tedious to seperate from the precipitate formed.

If it's any help, Sulfuric Acid is sold in Australia at 90% conc. for $40-$50 a liter. It is marketed as "Mo-Flo drain cleaner" in case they have it in England or America or wherever. It has "corrosion inhibitors", which means it is not chemically pure, however for the making of HNO3 the contaminants shouldn't have much effect. I use it for making esters mainly, and the purity of those seems to indicate that the "inhibitors" are not organic or volatile inorganic. I do not recomend distilling H2SO4 unless you have the proper equiptment, i tried and it had worse effects on me than when i leaked hundreds of liters (quite literally, i produced 10moles, with a large reaction vessel at 70~80*C) of Cl2 from a high pressure Sodium Chlorate vessel! It was mainly the fumes that the distillation process releases that do the damage, my eyes stung beneith the goggles and my lungs burned after 1 breath.. DO NOT TRY IT!! As for the whole NO2 dissolved thing.. all i can think is "where are you going to get the NO2?" as far as i no, the only real easy way to get it is to place copper (or a similar non-reactive metal) into conc. nitric acid, which kind of removes the need to make the NO2 in the first place.

Like the previous suggestion Al and NaOH are the cheapest (and i beleive most effective way) of producing large volumes of H2. I used a large (2L) round bottom flask full of Al foil (shredded with sissors) and dripped saturated NaOH (by means of an upside-down bottle) onto it at a rate which provided me with a constant flow of H2. The one thing i learnt however is make sure it is all air tight and free of O2, particularly if there is a risk of the jet igniting!

Reduce Sodium Chlorate (or any chlorate for that matter) with a strong acid, my suggestion would be HCl. I know that the reduction works, but i can only guess the equation... Not a good practice, but i am fairly confident in the products. 2NaClO3 + 4HCl --> 2NaCl + 2ClO2 + 2H2O + Cl2 ClO2 is not very nice, in fact it is quite horrible. Cl2 isn't great either, but in comparison to the ClO2, well, you catch my drift. NaClO3 is also very toxic, and it will kill plants very easily, so watch out for runoff. Obviously, stear it clear from waterways. Have fun