BPS-student Posted November 23, 2016 Share Posted November 23, 2016 Hello, I'm searching for some articles about te relation between 14-3-3 proteins and cancer, and especially the initiation and progression. The problem is I can't really find any clear articles. Is there someone who can tell me the relation or give me some articles where I can find it? Thanks! Link to comment Share on other sites More sharing options...
BabcockHall Posted December 8, 2016 Share Posted December 8, 2016 I went to Pubmed, searched "14-3-3 protein cancer" and I limited my search to review articles. I found 88 citations that way. Link to comment Share on other sites More sharing options...
StringJunky Posted December 8, 2016 Share Posted December 8, 2016 I went to Pubmed, searched "14-3-3 protein cancer" and I limited my search to review articles. I found 88 citations that way. But how many were pay-per-view? Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma Abstract: There are seven mammalian isoforms of the 14-3-3 protein, which regulate multiple cellular functions via interactions with phosphorylated partners. Increased expression of 14-3-3 proteins contributes to tumor progression of various malignancies. Several isoforms of 14-3-3 are overexpressed and associate with higher metastatic risks and poorer survival rates of hepatocellular carcinoma (HCC). 14-3-3β and 14-3-3ζ regulate HCC cell proliferation, tumor growth and chemosensitivity via modulating mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK) and p38 signal pathways. Moreover, 14-3-3ε suppresses E-cadherin and induces focal adhesion kinase (FAK) expression, thereby enhancing epithelial-mesenchymal transition (EMT) and HCC cell migration. 14-3-3ζ forms complexes with αB-crystallin, which induces EMT and is the cause of sorafenib resistance in HCC. Finally, a recent study has indicated that 14-3-3σ induces heat shock protein 70 (HSP70) expression, which increases HCC cell migration. These results suggest that selective 14-3-3 isoforms contribute to cell proliferation, EMT and cell migration of HCC by regulating distinct targets and signal pathways. Targeting 14-3-3 proteins together with specific downstream effectors therefore has potential to be therapeutic and prognostic factors of HCC. In this article, we will overview 14-3-3’s regulation of its downstream factors and contributions to HCC EMT, cell migration and proliferation. http://www.mdpi.com/2072-6694/7/2/0822/htm Link to comment Share on other sites More sharing options...
BabcockHall Posted December 9, 2016 Share Posted December 9, 2016 But how many were pay-per-view? 28 of 88 reviews were "free full text." You can ask Pubmed to give you this option. Here is one example: 14-3-3 proteins as potential therapeutic targets. Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. Semin Cell Dev Biol. 2011 Sep;22(7):705-12. doi: 10.1016/j.semcdb.2011.09.012. Review. PMID: 21983031 Free PMC Article Similar articles 1 Link to comment Share on other sites More sharing options...
StringJunky Posted December 9, 2016 Share Posted December 9, 2016 28 of 88 reviews were "free full text." You can ask Pubmed to give you this option. Here is one example: 14-3-3 proteins as potential therapeutic targets. Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. Semin Cell Dev Biol. 2011 Sep;22(7):705-12. doi: 10.1016/j.semcdb.2011.09.012. Review. PMID: 21983031 Free PMC Article Similar articles Right. That's handy to know. Link to comment Share on other sites More sharing options...
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