Cannabinoids and neural oscillations in the gamma range

[tkadm30]

The effects of cannabinoids on neural communication (synaptic plasticity) are poorly understood. Does cannabinoids (THC) fine-tune or disrupt neural oscillations in the gamma range? I find the hypothesis that THC may disrupt neural oscillations pretty much obsolete as there no evidences of disruption of synchrony by exogenous THC administration.

Edited January 18, 2017 by tkadm30

[CharonY]

How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?

 

Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.

[tkadm30]

How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?

 

Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.

 

I'm thinking of dopaminergic "fine-tuning" as a dopamine-mediated enhancement of synchrony in the gamma range. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697121/

[tkadm30]

Can THC, as a CB1 partial agonist, modulate dopamine cross-talk and synchrony in the gamma range?

[tkadm30]

Dopamine/CB1 receptor cross-talk = fine-tuning of dopamine D2 receptors = enhances cAMP activity

 

"Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?"

 

http://molpharm.aspetjournals.org/content/67/5/1697.short

 

cAMP is a promoter of calcium-dependent synaptic exocytosis.

Edited January 24, 2017 by tkadm30