Jump to content

Cannabinoids and neural oscillations in the gamma range


Recommended Posts

The effects of cannabinoids on neural communication (synaptic plasticity) are poorly understood. Does cannabinoids (THC) fine-tune or disrupt neural oscillations in the gamma range? I find the hypothesis that THC may disrupt neural oscillations pretty much obsolete as there no evidences of disruption of synchrony by exogenous THC administration.

Edited by tkadm30
Link to comment
Share on other sites

How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?

 

Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.

Link to comment
Share on other sites

How do you define "fine tune"? What specific adjustment would improve physiological responses and at which point would you consider it a disruption?

 

Most publications discussing disruptions of gamma band oscillations by THC are fairly recent do you have a key publication that directly refutes that?

We can start with this one here: Cortes-Briones et al Neuropsychopharmacology 2015 40(9). With the free version here.

 

I'm thinking of dopaminergic "fine-tuning" as a dopamine-mediated enhancement of synchrony in the gamma range. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697121/

Link to comment
Share on other sites

Dopamine/CB1 receptor cross-talk = fine-tuning of dopamine D2 receptors = enhances cAMP activity

 

"Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?"

 

http://molpharm.aspetjournals.org/content/67/5/1697.short

 

cAMP is a promoter of calcium-dependent synaptic exocytosis.

Edited by tkadm30
Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.