preparation of aspirin

[Sarahisme]

hey i am writing up my prac on the preparation of aspirin, and just can't seem to find any information on what the "published" or "accepted" yield is. In my experimetn i got 86% (which i think is a little high).

 

Cheers

 

Sarah

[Sarahisme]

oh yeah, i meant to ask...

 

where can i find this kind of information? (or this specific piece of information?)

[Sarahisme]

oh and likewise for paracetamol (if anyone knows where this kind of info. exists )

?

 

[Sarahisme]

lol, anyone at all?

[BenSon]

I'm not familiar with the preparation of aspirin. If it dosn't involve equilibriums and similar, your best bet is just to calculate the theoretical possible yield and compare yours to it.

 

~Scott

[Sarahisme]

yeah i have done that, but i was thinking that there would be a value for the yield that is got when it is done in industry or something like that...?

 

thanks for replying btw

[BenSon]

Maybe try emailing the companies, they could possibly help. I have no idea what the industry standard is.

 

~Scott

[Sarahisme]

ok ,will do, thanks BenSon

[Skye]

If you have access look up journals online, eg. journal of the american chemical society.

[budullewraagh]

out of curiosity, what precursor did you use, and what did you do to obtain your final product?

[Sarahisme]

precurser?

[budullewraagh]

what was the base chemical you started with in your synthesis?

[Sarahisme]

for aspirin it was salicylic acid and for paracetamol 4-aminophenol

[budullewraagh]

so basically you esterfied the salicylic acid with ethanoic acid and you formed the amide of para-aminophenol with ethanoic acid. what catalysts did you use?

[Sarahisme]

catalyst, ummm H2SO4 and acetic anhydride

[budullewraagh]

how conc was the H2SO4?

[Sarahisme]

dunno only used 6 drops of H2SO4

[Sarahisme]

but i think it was fairly strong

[budullewraagh]

well, you should have observed high yields

[Sarahisme]

ok yeah ,well 85% and 60% is good i suppose, so thanks

yep thanks everyone

[Crash]

Lol, we did this lab at teh start of this semester for my organic chem class (aspirin not paracetamol)