Idea for Drug Delivery through Mitochondria

[sullivjo]

The packing of drugs into mitochondria for administration and delivery to the site of action in vivo could be efficient as it could avoid immune response being an endogenous nanoparticle and be membrane permeable with improved drug lifetime. Attachment of mAbs to the outer membrane may direct it to the desired cells/site of action. This method may be also possible for gene therapy.

 

Is this method feasible or at least a worthwhile topic of research?

[Endy0816]

Did you mean exsomes(which they are looking into for this purpose)?

 

https://www.ncbi.nlm.nih.gov/pubmed/22776312

 

Nanoparticles are between 1-100 nm. Mitochondria fall outside that range.

[sullivjo]

Thanks for the correction, for some reason I associated mitochondria with nanoparticles. I was simply suggesting mitochondria as an alternative to exosomes.