SStell Posted June 20, 2017 Share Posted June 20, 2017 Is there a protein complex embedded in a membrane that uses H+ to attach a phosphate group onto ADP for each of the 8 nucleotides? dATP, dGTP, dTTP, dCTP, rATP, rGTP, rUTP, rCTP? Or can you link me with some information in this regards? Thanks. Link to comment Share on other sites More sharing options...
BabcockHall Posted June 20, 2017 Share Posted June 20, 2017 (edited) There is a single enzyme, ribonucleotide reductase, that reduces NDPs into dNDPs, where N = U, A, C, or G. In the case of dUDP, it is eventually converted into dTTP by an indirect route. Also look into the enzyme nucleoside diphosphokinase. IIRC it has broad specificity. Edited June 20, 2017 by BabcockHall Link to comment Share on other sites More sharing options...
SStell Posted June 20, 2017 Author Share Posted June 20, 2017 (edited) Thank you That helps me understand the conversion between deoxyribose and ribose but are all NTPs phosphorylated by one type of ATP synthase or are there multiple types of ATP synthases? Edited June 20, 2017 by SStell Link to comment Share on other sites More sharing options...
BabcockHall Posted June 20, 2017 Share Posted June 20, 2017 (edited) Once ADP is converted into ATP, the broad specificity of nucleoside diphosphokinase comes into play. Nelson and Cox's textbook has discussions of this enzyme in three locations. Edited June 20, 2017 by BabcockHall Link to comment Share on other sites More sharing options...
SStell Posted June 21, 2017 Author Share Posted June 21, 2017 Thank you Link to comment Share on other sites More sharing options...
BabcockHall Posted June 22, 2017 Share Posted June 22, 2017 ATP can provide the phosphoryl group to any NDP or dNDP via nucleoside diphosphokinase. Link to comment Share on other sites More sharing options...
BabcockHall Posted July 5, 2017 Share Posted July 5, 2017 @OP, This is just a guess, but were you asking because of an interest in mitochondrial depletion syndrome, which has been in the news recently? It seems that some forms of this disease are related to mutations in thymidine kinase 2 of mitochondria. This enzyme has a role in the salvage of deoxynucleotides, but I have not yet found a good review article. Link to comment Share on other sites More sharing options...
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