Are there 8 types of ATP Synthases?

[SStell]

Is there a protein complex embedded in a membrane that uses H+ to attach a phosphate group onto ADP for each of the 8 nucleotides? dATP, dGTP, dTTP, dCTP, rATP, rGTP, rUTP, rCTP? Or can you link me with some information in this regards? Thanks.

 

[BabcockHall]

There is a single enzyme, ribonucleotide reductase, that reduces NDPs into dNDPs, where N = U, A, C, or G. In the case of dUDP, it is eventually converted into dTTP by an indirect route. Also look into the enzyme nucleoside diphosphokinase. IIRC it has broad specificity.

Edited June 20, 2017 by BabcockHall

[SStell]

Thank you

 

That helps me understand the conversion between deoxyribose and ribose but are all NTPs phosphorylated by one type of ATP synthase or are there multiple types of ATP synthases?

Edited June 20, 2017 by SStell

[BabcockHall]

Once ADP is converted into ATP, the broad specificity of nucleoside diphosphokinase comes into play. Nelson and Cox's textbook has discussions of this enzyme in three locations.

Edited June 20, 2017 by BabcockHall

[SStell]

Thank you

[BabcockHall]

ATP can provide the phosphoryl group to any NDP or dNDP via nucleoside diphosphokinase.

[BabcockHall]

@OP, This is just a guess, but were you asking because of an interest in mitochondrial depletion syndrome, which has been in the news recently? It seems that some forms of this disease are related to mutations in thymidine kinase 2 of mitochondria. This enzyme has a role in the salvage of deoxynucleotides, but I have not yet found a good review article.