Vaccination: Partial cell lysate vs. specific proteins

[Elite Engineer]

Vaccinations can be as low as 40% effectiveness and as high as 95%. 

In thinking of ways to raise the efficiency of vaccines with < 50% prevention, wouldn't it be more advantageous to use part of a whole cell lysate (taking out the bad stuff)

than using a handful of proteins that produce immunogenicity? At least this way, you're catching all the small interactions with cell components/ proteins that you would miss with just using a

surface protein or flagellin. Sure, you may raise the immune reaction a bit, and produce an elevated fever, but this would be common place in time. If you get a colonoscopy (very short procedure)

you're out of commission for the whole day. 

 

your thoughts?

 

~EE