Jump to content

Lamin A


kyelzbub

Recommended Posts

I was reading an article today about a protein called Lamin A. From what I read the protein coats the outside of a cell's nucleus. Lamin A starts out as prelamin A, and the presence of an enzyme called Zmpste 24 matured the prelamin A into Lamin A. The DNA of cells has been found to repair properly when Lamin A is healthy, but any type of mutation will interupt this repair and cause aging to proceed. They are now developing inhibitors to the enzyme that would interupt the production of Lamin A and in cancerous cells and/or tumors cause aging and death of the cells. Yeah, possible cure to cancer. Well, this is not my question. My question is that if they can inhibit and destroy this Lamin A, wouldn't it also be possible to repair it? This would in turn not necessarily prolong life, but maybe make us more physically and mentally capable while we are alive? Anyone else know anything about this?

Link to comment
Share on other sites

To my knowledge, the damaged DNA cannot be effectively repaired in cells with a defected Lamin A at this point. It can only be efficiently repaired in normal cells. I believe all scientists have figured out at this point is that Lamin A is directly related to the aging process and now their main goal is to develop inhibitors which would theoretically disrupt the production of Lamin A, prevent the repair function in cancer cells, therefore bringing premature aging and death. And as you correctly stated, a solution to the elimination of defected Lamin A would bring us a step closer to the cure for cancer.

Link to comment
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.