Allele frequency

[ammanny]

please I want to ask in the exAC browser data the meaning of allele count, allel number, number of homozygotes and allele frequency 

 

thankx alot

[rodrigoniskier]

Hi. The raw counts (AC and AN) refer to the total number of chromosomes with this allele, and total that were able to be called (whether reference or alternate), respectively. Thus, the allele frequency is AC/AN. The number of homozygotes represents the number of individuals who were found to be homozygotes to that allele on each population studied.