Aging and turreptosis mechanism

[Tweak]

Scientists have discovered that the deteorioration of the tightly-packed bundles of DNA that are responsible for our normal cell functioning is actually reversible, and figuring out how this process works could enable new treatments for age-related diseases like Alzheimer’s.

What I would like to brainstorm in this forum, is where to start if one would like to implement or somehow imitate the process that the turreptosis jellyfish undergoes when it renews it cellular structure to never die. I know it is very difficult or perhaps even impossible to attempt equating the way this sea creature’s biology functions in human bodies, but I would like to seriously postulate this for debate. Is immortality achievable with current date science of any relevance to this subject and how can we create a “miracle” serum for human ingestion or intravenous injection to retard, reverse and/or even nulify aging?

Researchers from the Salk Institute in the US and the Chinese Academy of Science made the discovery while studying the underlying causes of Werner syndrome - a genetic disorder that causes affected individuals to age more rapidly than normal.

The team found that the genetic mutations responsible for this syndrome caused densely packed DNA - known as heterochromatin - to become destabilised, which serves to disrupt normal cellular functions and caused the cells to age prematurely.

“This has implications beyond Werner syndrome, as it identifies a central mechanism of aging - heterochromatin disorganisation - which has been shown to be reversible.”

 

The team also observed that the deletion of this gene led to the structural breakdown of heterochromatin. This bundling of DNA, which is found inside the cell’s nucleus, controls the activity of genes and helps the molecular machinery inside cells to function normally.

 

I propose: Let the scientific community gear some of its efforts towards identifying which proteins, blocks or substances the Turreptosis produces, and observing at the cellular level how this creature’s cellular components behave. Perhaps that substance can be sinthezised and trialed in other living creatures for observation. Tortoises and humb back whales live up to 200 years. Let’s look into that as well, and see how their cell structure behaves compared to that of an 18, 30, 50 and 80 year old human behaves. Can it be disrupted? Or slowed down significantly enough to extend human life span?

 

As part of their study, the researchers also tested stem cells from the dental pulp of healthy people across a wide age range. They found that older individuals, aged between 58 and 72, had fewer genetic markers for the DNA instability than people between the ages of seven and 25.

“What this study means is that this protein does not only work in a particular genetic disease, it works in all humans,” Belmonte affirms.

“More broadly, it suggests that accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging. This begs the question of whether we can reverse these alterations - like remodeling an old house or car - to prevent, or even reverse, age-related declines and diseases.”

Importantly, before it becomes anything close to heralding the fountain of youth we all crave, researchers will need to develop ways to specifically target, and safely edit, these genes in humans, rather than in petri dishes.

End of rant.

[Endy0816]

Turritopsis reverts to an earlier stage. Not something we can use directly unfortunately.

https://en.wikipedia.org/wiki/Turritopsis_dohrnii#Biological_immortality

 

Definitely studies going on.

https://en.wikipedia.org/wiki/Biological_immortality

We could probably at least increase how long we survive. Seen some decent success in mice via different routes.

[Tweak]

That is such a downer. I really appreciate your information but I’m kind of hoping to prove otherwise with the turreptosis biology applied to humans. I’ve spent half my life around studying and researching turreptosis and the greenland shark. Second most longest living animal. Pehaps the key lies in its genes. I feel that if I dedicate my life to it, I could make PhD based on my findings. Which I’m not sure I should, should I ever make a breakthrough. Political and military interests that may become “interested” and all... but I will never give up I promise. I can’t give up on the only potential and practical solution to not dying. But I’m supposing I have to be equally careful if I ever do. Keep it secret until a few generations till there’s no more wars in the very least?

Edited August 10, 2018 by Tweak

[Endy0816]

The Jellyfish lifecycle and biology is wildly different than ours. The greenland shark would be a safer bet as it is more similar to us. Note that, at least on the wiki, the oldest found is only listed as being at "392 ± 120 years".

https://en.wikipedia.org/wiki/Greenland_shark#Longevity

 

There is quite a bit of research going on into life extension. You don't have to imagine yourself as slaving alone in secret.

https://en.wikipedia.org/wiki/Life_extension#Research

Making steady progress I think.

[Tweak]

Just found this! Human cells successfully reversed!

https://www.facebook.com/479163965435700/posts/2064843523534395/